Simulating the Disposition of Budesonide from Dry Powder Inhalers (DPIs) and Nebulizers

Simulating the Disposition of Budesonide from Dry Powder Inhalers (DPIs) and Nebulizers

Conference: AAPS
Software: GastroPlus®
Division: PBPK

Objective: To simulate and predict the absorption and pharmacokinetics (PK) of budesonide following orally‐inhaled (OIN) i.e. respiratory administration across multiple formulations and/or devices.

Modeling Disposition of Budesonide Following Intravenous and Oral Administration in Healthy Adult Subjects

Modeling Disposition of Budesonide Following Intravenous and Oral Administration in Healthy Adult Subjects

Conference: AAPS
Software: GastroPlus®
Division: PBPK

Objective: To simulate and predict the absorption and pharmacokinetics(PK) of budesonide following intravenous(IV) and oral(PO) administrations.

Population Pharmacokinetic Evaluation of Eslicarbazepine Acetate for Adjunctive Therapy in Refractory Partial Onset Seizures

Population Pharmacokinetic Evaluation of Eslicarbazepine Acetate for Adjunctive Therapy in Refractory Partial Onset Seizures

Conference: AAPS

Eslicarbazepine acetate (ESL) is a once-daily antiepileptic drug (AED) that is converted to eslicarbazepine, the primary active metabolite of ESL, after oral administration. A population…

Assessing the Risk of pH-Dependent Absorption for New Molecular Entities: A Novel in Vitro Dissolution Test, Physicochemical Analysis, and Risk Assessment Strategy

Assessing the Risk of pH-Dependent Absorption for New Molecular Entities: A Novel in Vitro Dissolution Test, Physicochemical Analysis, and Risk Assessment Strategy

Publication: Mol Pharm
Software: GastroPlus®

Weak base therapeutic agents can show reduced absorption or large pharmacokinetic variability when coadministered with pH-modifying agents, or in achlorhydria disease states, due to...

Purely in-silico BCS classification: Science based quality standards for the world’s drugs

Purely in-silico BCS classification: Science based quality standards for the world’s drugs

Publication: Mol Pharm
Software: ADMET Predictor®

BCS classification is a vital tool in the development of both generic and innovative drug products. The purpose of this work was to provisionally classify the world's top selling oral drugs...

Comparison of in silico models for prediction of mutagenicity

Comparison of in silico models for prediction of mutagenicity

Publication: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
Software: ADMET Predictor®

Using a dataset with more than 6000 compounds, the performance of eight quantitative structure activity relationships (QSAR) models was evaluated: ACD/Tox Suite, Absorption, Distribution...

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin

Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin

Authors: Chiang PC, Wong H
Publication: AAPS J
Software: GastroPlus®

In the pharmaceutical industry, salt is commonly used to improve the oral bioavailability of poorly soluble compounds. Currently, there is a limited understanding on the solubility...

Validation of quantitative structure–activity relationship models to predict water-solubility of organic compounds

Validation of quantitative structure–activity relationship models to predict water-solubility of organic compounds

Publication: Sci Total Environ
Software: ADMET Predictor®

Water-solubility is an important physicochemical property in pharmaceutical and environmental studies. We assessed the performance of five predictive computer models: ACD/PhysChem History...

Is the full potential of the Biopharmaceutics Classification System reached?

Is the full potential of the Biopharmaceutics Classification System reached?

Publication: Eur J Pharm Sci
Software: ADMET Predictor®

In this paper we analyse how the biopharmaceutics classification system (BCS) has been used to date. A survey of the literature resulted in a compilation of 242 compounds for which BCS classes were reported.

Bioisosteric approach in designing new monastrol derivatives: an investigation on their ADMET prediction using in silico derived parameters

Bioisosteric approach in designing new monastrol derivatives: an investigation on their ADMET prediction using in silico derived parameters

Publication: J Mol Graph Model
Software: ADMET Predictor®

Medicinal chemists are facing an increasing challenge to deliver safer and more effective medicines. An appropriate balance between drug-like properties such as solubility, permeability, metabolic stability...

Profiling Biopharmaceutical Deciding Properties of Absorption of Lansoprazole Enteric-Coated Tablets Using Gastrointestinal Simulation Technology

Profiling Biopharmaceutical Deciding Properties of Absorption of Lansoprazole Enteric-Coated Tablets Using Gastrointestinal Simulation Technology

Publication: Int J Pharm
Software: GastroPlus®

The aim of the present study was to correlate in vitro properties of drug formulation to its in vivo performance, and to elucidate the deciding properties of oral absorption.

Tedizolid Population Pharmacokinetics, Exposure-Response, and Target Attainment

Tedizolid Population Pharmacokinetics, Exposure-Response, and Target Attainment

Conference: ICAAC

Tedizolid phosphate is a novel antibiotic prodrug rapidly converted by phosphatases to its active moiety tedizolid after administration. Tedizolid is 4-16 fold more potent in vitro than linezolid against…