Net sales increase 15.3% to first quarter record $2.641 million; Earnings up 16.7%
Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium
Pyrvinium pamoate (PP) is a potent noncompetitive inhibitor of the androgen receptor (AR). Using a novel method of target identification, we demonstrate that AR is a...
Evaluation and Optimisation of Current Milrinone Prescribing for the Treatment and Prevention of Low Cardiac Output Syndrome in Paediatric Patients After Open Heart Surgery Using a Physiology-Based Pharmacokinetic Drug-Disease Model
Milrinone is the drug of choice for the treatment and prevention of low cardiac output syndrome (LCOS) in paediatric patients after open heart surgery across Europe.
Population Pharmacokinetic Evaluation of Eslicarbazepine Acetate for Adjunctive Therapy in Refractory Partial Onset Seizures
Eslicarbazepine acetate (ESL), a once-daily antiepileptic drug (AED), is converted to eslicarbazepine, the primary active metabolite of ESL, after oral administration. The population pharmacokinetics (PK)…
Design, Synthesis, and in vitro Testing of Novel COX-2/COX-1 Inhibitors
To design,synthesize,and test new lead molecules that inhibit both COX-1 and COX-2 forms of the cyclooxygenase (COX) enzyme, with higher affinity for COX-2 than for COX-1.
Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury
The drug development industry faces multiple challenges in the realization of safe effective drugs.
Faruqi & Faruqi, LLP Launches An Investigation Against Simulations Plus, Inc. (SLP) For Potential Breaches Of Fiduciary Duties By Its Board Of Directors
Faruqi & Faruqi, LLP, a leading national securities firm headquartered in New York City, is investigating the Board of Directors of Simulations Plus, Inc.
The Value of a Conceptual Schema
This year represents the 60th anniversary of the publication of the famous paper by James Watson and Francis Crick proposing a structure for DNA. This podcast from Nature contains interviews with scientists who were actively involved in the race to work out the structure. Listen to the podcast. At approximately 7 minutes into the podcast, there is a remarkable description of Watson’s first look at the classic x-ray crystallography picture of DNA. Watson knew immediately what the picture represented because Crick had, two years previously, published a theoretical paper about what a helical diffraction pattern
would look like.
Simulations Plus Reports Preliminary Revenues for First Fiscal Quarter FY2014
Revenues Increase 14.9% for New Record 1st Quarter
Small molecule kinase inhibitors approved by the FDA from 2000 to 2011: a systematic review of preclinical ADME data
Fourteen drugs targeting protein kinases have been approved by the United States Food and Drug Administration (FDA) between the years 2000 and 2011.
3D QSAR and pharmacophore study of curcuminoids and curcumin analogs: Interaction with thioredoxin reductase
Curcumin is the yellow pigment of Curcuma longa that irreversibly inhibits the activity of thioredoxin reductase (TrxR) and forms adduct.
Simulations Plus Announces Change in Chief Financial Officer
John R. Kneisel, CPA, to Replace Momoko Beran, Retiring after More Than 20 Years of Service
The Inspiration of Great Architecture
Buffalo is home to truly spectacular architecture. We have many landmark buildings, historic sites, and cultural attractions and to appreciate them is to be reminded that Western New York was once at the cutting edge of architecture and landscape design that served to make Buffalo an aesthetically pleasing place to live and work. These works of art were conceived and built during a time of remarkable wealth generated as a result of Buffalo’s location at the western terminus of the Erie Canal and a transportation hub for goods moving between the Mid-West and East Coast.
Small-molecule inhibitors of the androgen receptor
The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof.
Simulations Plus to Present at the LD MICRO Sixth Annual Conference
Leading Provider of Simulation and Modeling Software for Pharmaceutical Discovery and Development to Present on December 3, 2013
Simulations Plus Reports FY2013 and Fourth Quarter FY2013 Financial Results
Fiscal Year Pharmaceutical Software and Services Up 6.6%
Preoperative androgen deprivation therapy for localized prostate cancer: delayed biochemical recurrence in high-risk disease
Background: The role of preoperative ADT for localized prostate cancer is controversial; prospective assessments have yielded varying results. We sought to define a subset...
Largest Chinese CRO, WuXi PharmaTech, Purchases Multiyear ADMET Predictor License
Toxicity predictions to be used to supplement in vitro data as a service
Prediction of Valsartan Pharmacokinetics in Pediatric Population using Physiologically Based Pharmacokinetic (PBPK) Model
A method for transporter-based in vitro-in vivo extrapolation (IVIVE) was previously developed and demonstrated by predicting valsartan PK after i.v.administration [1]. The purpose of this study was to…
MembranePlus™: A Tool to Study in vitro/in vivo Transport and Drug-Drug Interaction
To develop a mechanistic mathematical model for analysis of in vitro permeability assays that accounts for all mechanisms contributing to observed apparent permeability: passive paracellular and…