Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption

Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption

Authors: Suenderhauf C, Tuffin G, Lorentsen H, Grimm HP, Flament C, Parrott N
Publication: Pharm Res
Keywords: absorption, acetaminophen, area under curve, biological availability, biological models, gastric emptying, intravenous injections, metabolism, non-narcotic analgesics, oral administration
Software: GastroPlus®

Onset and rate of gastric emptying are important determinants of drug absorption after oral dosing.

Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification

Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification

Authors: Cvijić S, Parojcić J, Langguth P
Publication: Eur J Pharm Sci
Keywords: absorption simulation, disintegration, dissolution, food effect, poorly-permeable drugs, viscosity
Software: GastroPlus®

Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate.

Detection and phenotyping of circulating tumor cells in high-risk localized prostate cancer

Detection and phenotyping of circulating tumor cells in high-risk localized prostate cancer

Authors: Pal SK, He M, Wilson T, Liu X, Zhang K, Carmichael C, Torres A, Hernandez S, Lau C, Agarwal N, Kawachi M, Yen Y, Jones JO
Publication: Clin Genitourin Cancer
Keywords: CD133, CellSearch, EMT, Fragment, stem cell

Background: In this study, we aimed to determine the feasibility of identifying CTCs in patients with HRLPC, using a modified isolation procedure using the CellSearch...

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: A comparison with carbamazepine, oxcarbazepine and lacosamide

Authors: Hebeisen S, Pires N, Loureiro AI, Bonifácio MJ, Palma N, Whyment A, Spanswick D, Soares-da-Silva P
Publication: Neuropharmacology
Keywords: Carbamazepine, eslicarbazepine, fast inactivation, lacosamide, oxcarbazepine, slow inactivation, voltage-gated sodium channel
Software: ADMET Predictor®

This study aimed at evaluating the effects of eslicarbazepine, carbamazepine (CBZ), oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of voltage-gated sodium channels (VGSC).

Computational Predictions of Glass-Forming Ability and Crystallization Tendency of Drug Molecules

Computational Predictions of Glass-Forming Ability and Crystallization Tendency of Drug Molecules

Authors: Alhalaweh A, Alzghoul A, Kaialy W, Mahlin D, Bergstrom CAS
Publication: Mol Pharm
Keywords: bonding, chemistry, computer simulation, crystallization, hydrogen, molecular weight, pharmaceutical methods, pharmaceutical preparations, solubility
Software: ADMET Predictor®

Amorphization is an attractive formulation technique for drugs suffering from poor aqueous solubility as a result of their high lattice energy.

RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma

RNA-seq reveals aurora kinase-driven mTOR pathway activation in patients with sarcomatoid metastatic renal cell carcinoma

Authors: Pal SK, He M, Tong T, Wu H, Liu X, Lau C, Wang JH, Warden C, Wu X, Signoretti S, Choueiri TK, Karam JA, Jones JO
Publication: Mol Cancer Res
Keywords: metastatic, renal cell carcinoma, RNA sequencing, sarcomatoid

Sarcomatoid metastatic renal cell carcinoma (mRCC) is associated with a poor prognosis, and the biology of the disease has been inadequately characterized.

Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin

Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin

Authors: Parrott N, Hainzl D, Scheubel E, Krimmer S, Boetsch C, Guerini E, Martin-Facklam M
Publication: AAPS J
Keywords: animals, antipsychotic agents, biological availability, biological models, computer simulation, humans, intestinal absorption, oral administration, Physiologically based pharmacokinetic (PBPK) modeling, piperazines, solubility, Sulfones
Software: GastroPlus®

Bitopertin (RG1678) is a glycine reuptake inhibitor in phase 3 trials for treatment of schizophrenia. Its clinical oral pharmacokinetics is sensitive to changes in drug substance particle size and dosage form.

Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

Discovery of furan-2-carbohydrazides as orally active glucagon receptor antagonists

Authors: Hasegawa K, Niidome K, Migihashi C, Murata M, Negoro T, Matsumoto T, Kato K, Fujii A
Publication: Bioorg Med Chem Lett.
Keywords: ADME/Tox properties, furan-2-carbohydrazide, glucagon, glucagon receptor antagonist, hyperglucagonemia, Type 2 diabetes
Software: ADMET Predictor®

Furan-2-carbohydrazides were found as orally active glucagon receptor antagonists. Starting from the hit compound 5, we successfully determined the structure activity relationships of a series...

In Silico Prediction of Major Drug Clearance Pathways by Support Vector Machines with Feature-Selected Descriptors

In Silico Prediction of Major Drug Clearance Pathways by Support Vector Machines with Feature-Selected Descriptors

Authors: Toshimoto K, Wakayama N, Kusama M, Maeda K, Sugiyama Y, Akiyama Y
Publication: Drug Metab Dispos
Keywords: computer simulation, in silico, pharmacokinetics, support vector machine
Software: ADMET Predictor®

We have previously established an in silico classification method ("CPathPred") to predict the major clearance pathways of drugs based on an empirical decision with only four physicochemical...