This research was motivated due to substantial requirement of improved treatment for breast cancer which accounts for over 0.52 million deaths annually worldwide.
Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics.
The relative bioavailability of lanabecestat administered as 2 tablet formulations versus an oral solution was investigated.
In vitro to in vivo extrapolation for high throughput prioritization and decision making
In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk.
Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers
To understand hydrolysis and alcoholysis of polyvinylpyrrolidone-co-vinylacetate (PVPVA) during formulation and storage, elucidate the reaction mechanism, establish an intrinsic kinetic model, and apply...
The androgen receptor malignancy shift in prostate cancer
Background: Androgens and the androgen receptor (AR) are necessary for the development, function, and homeostatic growth regulation of the prostate gland. However...
The Role of Circulating Tumor DNA in Renal Cell Carcinoma
Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) is a novel technology that can complement tumor tissue NGS and has the potential to influence...
What’s new in PKPlus™ version 2?
In this webinar, we will demonstrate how PKPlus 2 combines functionality and flexibility for all PK analyses, providing the capabilities to meet the needs of scientists across departments at...
Monitoring of erlotinib in pancreatic cancer patients during long-time administration and comparison to a physiologically based pharmacokinetic model
In this study, a therapeutic drug monitoring (TDM) of erlotinib in pancreatic cancer patients was performed over 50 weeks to reveal possible alterations in erlotinib plasma concentrations.
Coupled in silico platform: Computational fluid dynamics (CFD) and physiologically-based pharmacokinetic (PBPK) modelling
One of the critical components of the respiratory drug delivery is the manner in which the inhaled aerosol is deposited in respiratory tract compartments.
Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs.
Prediction of local exposure following inhalation of a locally acting pulmonary drug is central to the successful development of novel inhaled medicines, as well as generic equivalents.
Data Projects Medical Technologies Market to Expand
FinancialBuzz.com News Commentary
Converting In Vitro Permeability to Effective Jejunum Permeabililty
This video is a demonstration of Tutorial 5.3.3. It shows how to create a correlation between apparent permeability and effective jejunum permeability.
In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials
Current strategies to delineate the risk of serious drug-induced liver injury associated with drugs rely on assessment of serum biomarkers that have been utilized for many decades.
Cognitive Engineering – The Tools, Mindset, and Strategy for an Integrated Development Standard
Internet technology facilitates connectedness but often fails to foster collaboration. Advanced modeling techniques can provide insight for development discussions, but in many cases, these tools…
Pharmacokinetic Analysis of Gatilfoxacin in Plasma and Sinus Aspirate Drug Treatment of Maxiliary Sinusitis
A novel approach to collect sinus exudate was utilized and the time course of gatifloxacin (GAT) in the blood and at the primary infection site were assessed during treatment for acute maxillary sinusitis (AMS).
A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models
Parameter sensitivity and uncertainty analysis for physiologically based pharmacokinetic (PBPK) models are becoming an important consideration for regulatory submissions, requiring further...
Food effects in paediatric medicines development for products Co-administered with food
A small amount of food is commonly used to aid administration of medicines to children to improve palatability and/or swallowability.
Pharmacokinetics And Exposure-Response Relationships Of Dasotraline In The Treatment Of Attention-Deficit/Hyperactivity Disorder In Adults
To characterize the pharmacokinetic and pharmacodynamic data to explore the time course and exposure response relationships in Phase 2 to define dasotraline benefit to risk relationship in adult Attention...
Characterization of Population Pharmacokinetics of Cariprazine and Its Major Metabolites
Population pharmacokinetic (PK) analysis was undertaken to describe the concentration‑time profiles of cariprazine and its 2 major metabolites of similar pharmacological activity, desmethyl‑cariprazine...