Prediction of in vitro dermal delivery and drug in receptor fluid should be done using Nielsen model for vehicle evaporation...
Cosmetics Europe Evaluation of 6 in silico Skin Penetration Models
The Cosmetics Europe (CosEche) ADME Task Force aims to evaluate and develop in silico skin penetration models using relevant measured values.
Mechanistic Modeling Of Mitochondrial Biogenesis Within Dilisym Could Explain Clinically Observed Adaptation Of Serum Alanine Aminotransferase Elevations
Resolution of serum ALT elevations despite continued drug dosing, termed “adaptation”, is commonly observed in clinical trials, but the underlying mechanisms behind this phenomenon remain unclear.
Prediction of the Liver Toxicity of the Endothelin Receptor Antagonists Sitaxsentan and Ambrisentan for the Treatment of Pulmonary Arterial Hypertension with a Quantitative Systems Toxicology Tool (DILIsym)
Sitaxsentan and ambrisentan are highly selective endothelin-1 type A receptor antagonists which were developed for the treatment of pulmonary arterial hypertension.
Applying in silico-in vitro-in vivo extrapolation (IS-IVIVE) techniques to predict exposure and guide risk assessment
Combining QSAR, PBPK, and QST models is a powerful approach to getting more information out of your data investments early in product development.
In Vitro, in Silico, and in Vivo Assessments of Intestinal Precipitation and Its Impact on Bioavailability of a BCS Class 2 Basic Compound
In this study, a multipronged approach of in vitro experiments, in silico simulations, and in vivostudies was developed to evaluate the dissolution, supersaturation, precipitation, and...
Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth
Creatine is an ergogenic compound used by athletes to enhance performance. Supplementation with creatine monohydrate (CM) has been suggested for musculoskeletal and neurological disorders.
Process optimization and in vivo performance of docetaxel loaded PHBV-TPGS therapeutic vesicles: A synergistic approach.
This research was motivated due to substantial requirement of improved treatment for breast cancer which accounts for over 0.52 million deaths annually worldwide.
Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics.
The relative bioavailability of lanabecestat administered as 2 tablet formulations versus an oral solution was investigated.
In vitro to in vivo extrapolation for high throughput prioritization and decision making
In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk.
Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers
To understand hydrolysis and alcoholysis of polyvinylpyrrolidone-co-vinylacetate (PVPVA) during formulation and storage, elucidate the reaction mechanism, establish an intrinsic kinetic model, and apply...
The androgen receptor malignancy shift in prostate cancer
Background: Androgens and the androgen receptor (AR) are necessary for the development, function, and homeostatic growth regulation of the prostate gland. However...
The Role of Circulating Tumor DNA in Renal Cell Carcinoma
Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) is a novel technology that can complement tumor tissue NGS and has the potential to influence...
What’s new in PKPlus™ version 2?
In this webinar, we will demonstrate how PKPlus 2 combines functionality and flexibility for all PK analyses, providing the capabilities to meet the needs of scientists across departments at...
Monitoring of erlotinib in pancreatic cancer patients during long-time administration and comparison to a physiologically based pharmacokinetic model
In this study, a therapeutic drug monitoring (TDM) of erlotinib in pancreatic cancer patients was performed over 50 weeks to reveal possible alterations in erlotinib plasma concentrations.
Coupled in silico platform: Computational fluid dynamics (CFD) and physiologically-based pharmacokinetic (PBPK) modelling
One of the critical components of the respiratory drug delivery is the manner in which the inhaled aerosol is deposited in respiratory tract compartments.
Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs.
Prediction of local exposure following inhalation of a locally acting pulmonary drug is central to the successful development of novel inhaled medicines, as well as generic equivalents.
Data Projects Medical Technologies Market to Expand
FinancialBuzz.com News Commentary
Converting In Vitro Permeability to Effective Jejunum Permeabililty
This video is a demonstration of Tutorial 5.3.3. It shows how to create a correlation between apparent permeability and effective jejunum permeability.
In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials
Current strategies to delineate the risk of serious drug-induced liver injury associated with drugs rely on assessment of serum biomarkers that have been utilized for many decades.