Company Reports Record Fourth-Quarter and Full-Year Revenues
Development of long-circulating docetaxel loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles: optimization, pharmacokinetic, cytotoxicity and in vivo assessments
Long-circulating Nanoparticles (NPs) are promising drug delivery vehicles which target solid tumors via enhanced permeation and retention effect.
In Vitro Evaluation of Absorption Characteristics of Peramivir for Oral Delivery
Peramivir is a novel antiviral agent approved for the treatment of severe influenza.
Pharmacokinetics of Tedizolid in Obese and Nonobese Subjects
Obesity, defined as body mass index (BMI) 30 kg/m2, is a growing problem worldwide; the prevalence is 38% in the US adult population.
Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm
Despite an improved understanding of the molecular mechanisms of nociception, existing analgesic drugs remain limited in terms of efficacy in chronic conditions, such as neuropathic pain.
Computer Simulation in Pharmacokinetic and Pharmacodynamic Studies
Computer simulation in the field of Pharmacokinetic and Pharmacodynamics or in silica model is need of the hour in the biomedical field.
Modeling Tolerance Development for the Effect on Heart Rate of the Selective S1P1 Receptor Modulator Ponesimod
Ponesimod is a selective sphingosine-1-phosphate-1 (S1P1 ) receptor modulator currently under investigation for the treatment of multiple sclerosis.
Understanding dermal drug disposition using TCAT™ – a novel PBPK model
Scientists from GlaxoSmithKline and Simulations Plus have collaborated to develop a mathematical model, Transdermal Compartmental Absorption & Transit (TCAT™), that allows better understanding of drug penetration through the skin while accounting for the formulation characteristics, evaporation and precipitation effects that influence dermal delivery.
Sarcomatoid Renal Cell Carcinoma: The Apple Doesn’t Fall Far from the Tree
The most comprehensive sequencing effort of sarcomatoid renal cell carcinoma (sRCC) to date reinforces the notion that the sarcomatoid component is closely related to the...
Looking to the future of drug-induced liver injury: an interview with Paul B Watkins
Paul Watkins talks to Francesca Lake, Head of Open Access Publishing: Paul is The Howard Q Ferguson Professor in the Eshelman School of Pharmacy at The University of North Carolina at Chapel Hill (UNC, NC, USA), and an expert in drug safety and drug-induced liver injury (DILI).
MembranePlus™ v2 webinar: Stimulate your kinetic understanding…
We are pleased to announce the release of MembranePlus™ v2! This version takes modeling of in vitro systems to the next level, allowing you to capture all relevant information from your experiments.
Population Pharmacokinetic Evaluation and Missed-Dose Simulations for Eslicarbazepine Acetate Monotherapy in Patients With Partial-Onset Seizures
Given the potential consequences of antiepileptic therapy nonadherence, missed-dose scenarios of 12- to 48-hour dose delays (4-hour intervals) for eslicarbazepine acetate monotherapy...
In vitro and in vivo evaluation of gastro-retentive carvedilol loaded chitosan beads using GastroPlus™
The objective of present investigation was to develop gastro-retentive controlled release system of carvedilol using biological macromolecule, chitosan. 32 full factorial design was adopted for...
Population Pharmacokinetic and Pharmacodynamic Modeling of LY2510924 in Patients with Advanced Cancer.
The objectives of this study were to characterize the pharmacokinetics (PK) of LY2510924, a potent peptide antagonist of the CXCR4 receptor, after subcutaneous administration in patients with...
Discovery of Resistance Pathways to Fibroblast Growth Factor Receptor inhibition in Bladder Cancer
Background Aberrant fibroblast growth factor receptor (FGFR) signaling drives the growth of many bladder cancers. NVP-BGJ398 is a small molecule with potent inhibitory...
Biorelevant Dissolution Models for a Weak Base To Facilitate Formulation Development and Overcome Reduced Bioavailability Caused by Hypochlordyria or Achlorhydria.
In this study, two dissolution models were developed to achieve in vitro–in vivo relationship for immediate release formulations of Compound-A, a poorly soluble weak base with pH-dependent...
Simulations Plus Releases MembranePlus™ Version 2
Major update incorporates new models and tighter integration with GastroPlus™
Synthesis, antioxidant, antifungal, molecular docking and ADMET studies of some thiazolyl hydrazones
Some thiazolyl hydrazones were synthesized by one pot reaction of thiophene-2-carbaldehyde or 2, 4-dichlorobenzaldehyde, thiosemicarbazide and various phenacyl bromides which were preliminarily...