Cimaglermin alfa (GGF2) is a recombinant human protein growth factor in development for heart failure.
Software based approaches for drug designing and development: A systematic review on commonly used software and its applications.
Drug discovery include drug designing and development, is a multifarious and expensive endeavor, where least number of drugs that pass the clinical trials makes it to market.
Phase 1 and pharmacokinetic study of LY3007113, a p38 MAPK inhibitor, in patients with advanced cancer
Background The signaling protein p38 mitogen-activated protein kinase (MAPK) regulates the tumor cell microenvironment, modulating cell survival, migration, and invasion.
Modeling of prolactin response following dopamine D2 receptor antagonists in rats: can it be translated to clinical dosing?
Prolactin release is a side effect of antipsychotic therapy with dopamine antagonists, observed in rats as well as humans.
Mechanistic In Vitro Dissolution PBPK Models to Drive Drug Development
In this webinar, DDDPlus™, an in vitro simulation platform focused on providing predictive dissolution & precipitation tools for formulation development, will be presented in conjunction with GastroPlus™ to...
Simulations Plus Releases ADMET Predictor™ Version 8.5
New HTPK Simulation Module allows chemists to screen compound libraries using novel approach
2017 White Paper on recent issues in bioanalysis: aren’t BMV guidance/guidelines ‘Scientific’? (Part 1 – LCMS: small molecules, peptides and small molecule biomarkers)
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California from 3 April 2017 to 7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide.
A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core bodytemperature reduction by the TRPM8 blocker PF-05105679.
PF-05105679 is a moderately potent TRPM8 blocker which has been evaluated for the treatment of cold pain sensitivity.
Modeling of Active Transport and Metabolism for Hepatocyte Assays with Application of In Vitro to In Vivo Extrapolation (IVIVE)
Sandwich and suspended hepatocyte cultures are routinely used to assess either active transport and/or metabolism of drug molecules.
Development of In Vitro-In Vivo Correlation for Long Acting Injectable Microsphere Formulations
The concept of in vitro-in vivo correlations (IVIVCs) for long-acting injectable (LAI) microsphere formulations has gained more significance in the past decade.
Application of Physiologically Based Pharmacokinetic (PBPK) Models in Predicting Drug Pharmacokinetics for Different Ethnic Groups
The purpose of this study was to evaluate the ability of PBPK models to predict the pharmacokinects (PK) of different compounds in two ethnic groups, Caucasian and Chinese.
Simulations Plus Reports FY2017 and Fourth Quarter FY2017 Financial Results
Full Fiscal Year Pharmaceutical Software and Services Revenues Up 20.9%;
Earnings per share of $0.33, up 14.9% over prior year
Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.
Ribociclib (KISQALI®), a cyclin-dependent kinase 4/6 inhibitor approved for the first-line treatment of HR+/HER2– advanced breast cancer with an aromatase inhibitor, is administered with...
ADMET Predictor 8.5 Release Notes
Many major enhancements have been made throughout ADMET Predictor for this release.
Intrinsic dissolution simulation of highly and poorly soluble drugs for BCS solubility classification
Intrinsic dissolution testing allows characterizing drug substances through its dissolution rate when exposed to a specified surface area in a specific dissolution media.
ADMET Predictor™ v8.5 Webinar – Discover ‘Discovery PBPK’: Efficiently use PBPK modeling to drive lead selection & optimization
In this video, Michael Lawless discusses how to efficiently screen large compound libraries in minutes based on predicted in vivo fraction absorbed (Fa%) or oral bioavailability (F%) in virtual rats...