Eslicarbazepine acetate (ESL) is a once-daily oral antiepileptic drug (AED) indicated for partial-onset seizures (POS). ESL pharmacokinetics (PK) and exposure-response analyses were supported by...
The role of peroxisome proliferator-activated receptor gamma in prostate cancer
Despite great progress in the detection and treatment of prostate cancer, this disease remains an incredible health and economic burden. Although androgen receptor (AR)...
Ethanolic Extract of Pomegranate (Punica Granatum L) Peel: Acute Toxicity Tests on Zebrafish (Danio rerio) Embryos and its Toxicity Prediction by in silico
Antibiotic resistance causes many serious health problems that have emerged both in developed and developing countries. One of many examples of the antibiotic problem is resistance to Mycobacterium…
Relationship Between Fremanezumab Exposure and Efficacy in Preventive Therapy of Chronic Migraine in Adults
Fremanezumab is a fully humanized IgG2Δa/kappa monoclonal antibody that selectively targets calcitonin gene-related peptide (CGRP).
Relationship Between Fremanezumab Exposure and Efficacy in Preventive Therapy of Episodic Migraine in Adults
Fremanezumab is a fully humanized IgG2Δa/kappa monoclonal antibody that selectively targets calcitonin gene-related peptide (CGRP).
Lack of Relationship Between Fremanezumab Exposure and Cardiovascular Adverse Events in Phase 2 and Phase 3 Data Including Chronic and Episodic Migraine Patients
Fremanezumab is a fully humanized IgG2Δa/kappa monoclonal antibody that selectively targets calcitonin gene-related peptide (CGRP). Previously, fremanezumab was found to be effective and…
Applying MAM/PBPK Modeling to Predict Positive/Negative Food Effects: Approaches and Special Considerations
It is widely recognized that food can affect the absorption of orally administered drugs. In the course of pharmaceutical development, food is evaluated clinically as part of the early single or multiple ascending dose studies; additional evaluations often take place when there are formulation changes. The outcome of these studies informs dosing instructions both during the conduct of clinical trials as well as on the product label.
Simulations Plus Releases ADMET Predictor™ Version 9
Improvements to AI technology and extensions to HTPK Simulation Module further support discovery research efforts
Food for thought: formulating away the food effect – a PEARRL review
Co‐ingestion of oral dosage forms with meals can cause substantial changes in bioavailability relative to the fasted state. Food‐mediated effects on bioavailability can have significant consequences...
In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review
Drug precipitation in vivo poses a significant challenge for the pharmaceutical industry.
Simulations Plus Names Shawn O’Connor as CEO
Executive with relevant expertise in multiple industries succeeds retiring CEO Walt Woltosz, who remains chairman of the board
Pharmacokinetic/Pharmacodynamic Model of CW002, an Investigational Intermediate Neuromuscular Blocking Agent, in Healthy Volunteers
CW002 is an investigational non-depolarizing, neuromuscular blocking agent with a rapid onset and intermediate duration of
Computational Toxicology Methods in Chemical Library Design and High-Throughput Screening Hit Validation
The discovery of molecular toxicity in a clinical drug candidate can have a significant impact on both the cost and timeline of the drug discovery process.
ADMET Predictor 9 Release Notes
This new release of ADMET Predictor includes significant enhancements to the recently introduced HTPK Simulation Module, as well as to the MedChem Studio™ module and ADMET Modeler™
Development of a Clinically Relevant Dissolution Method for Metaxalone Immediate Release Formulations Based on an IVIVC Model
The aim of the present work was to classify metaxalone according to the Biopharmaceutics Classification System (BCS), to develop a clinically relevant dissolution method that can be used to predict...
The India GastroPlus™ User Group Webinar: Using In Silico Inputs to Inform GastroPlus Models
Significant enhancements have been made to the HTPK Simulation, MedChem Studio™, and ADMET Modeler™ modules in ADMET Predictor 9.
Brief overview of solubility methods: Recent trends in equilibrium solubility measurement and predictive models
Solubility is a crucial physicochemical parameter affecting the whole process of drug discovery and development.
Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity
New approaches are needed to assess the effects of inhaled substances on human health.
Antibacterial and antibiofilm activities of Prangos acaulis Bornm. extract against Streptococcus mutans: an in silico and in vitro study
Streptococcus mutans is a principal pathogenic agent in biofilm formation on the teeth surfaces and subsequently development of dental caries and plaque.