Amparo de la Peña, Vice President of Pharmacometrics at Simulations Plus, will join Jeff Sachs, Pavan Vaddady and Hao Zhu as new board members for 2024.
![Contributed data, collaboration and experience with ionization models – Part 1. Bayer Pharmaceuticals](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Contributed data, collaboration and experience with ionization models – Part 1. Bayer Pharmaceuticals
World‘s best in class pKa prediction tool
![Utilizing pKa Values for Effective Crop Protection: On Systemicity and Efficacy of Molecules](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Utilizing pKa Values for Effective Crop Protection: On Systemicity and Efficacy of Molecules
pKa important factor in research screening cascade of molecules
![November 2023 News/Events](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
November 2023 News/Events
Are your clinical trials showing potential liver toxicity?
![Development of an Ocular PBPK-PD model to predict drug-mediated intraocular pressure reduction in preclinical species](https://www.simulations-plus.com/wp-content/uploads/D-s-1200x1080.jpg)
Development of an Ocular PBPK-PD model to predict drug-mediated intraocular pressure reduction in preclinical species
Glaucoma, caused by an elevation of the intra-ocular pressure (IOP), leads to vision loss
![The Keys to Making Good Models from Chemical Structures](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
The Keys to Making Good Models from Chemical Structures
There are many different things that make a model "good."
![Adult and pediatric physiologically-based biopharmaceutics modeling to explain lamotrigine immediate release absorption process](https://www.simulations-plus.com/wp-content/uploads/Adult-process-1-1200x1080.jpg)
Adult and pediatric physiologically-based biopharmaceutics modeling to explain lamotrigine immediate release absorption process
Physiologically-based biopharmaceutics modeling (PBBM) has potential to accelerate the development of new drug and formulations.
![The QST modeling approach leveraging known physiology and available clinical data paves the path towards predictions of DILI in pediatrics](https://www.simulations-plus.com/wp-content/uploads/T-p-1200x1080.jpg)
The QST modeling approach leveraging known physiology and available clinical data paves the path towards predictions of DILI in pediatrics
Drug-induced liver injury (DILI) is an underrecognized cause of pediatric liver disease which accounts for almost...
![Improving pKa modelling through active collaborations](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Improving pKa modelling through active collaborations
What needs to be completed for collaboration?
![Impact of collaborative pKa modelling](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Impact of collaborative pKa modelling
Importance of pKa in Drug Discovery
![Quercetin-encapsulated magnetoliposomes: Fabrication, optimization, characterization, and antioxidant studies](https://www.simulations-plus.com/wp-content/uploads/Quercetin-studies-1200x1080.jpg)
Quercetin-encapsulated magnetoliposomes: Fabrication, optimization, characterization, and antioxidant studies
Quercetin (QU) faces challenges in its therapeutic efficacy due to its hydrophobic nature and limited oral bioavailability.
![Approaches to Account for Colon Absorption in Physiologically Based Biopharmaceutics Modeling of Extended-Release Drug Products](https://www.simulations-plus.com/wp-content/uploads/Approaches-products-1200x1080.jpg)
Approaches to Account for Colon Absorption in Physiologically Based Biopharmaceutics Modeling of Extended-Release Drug Products
The rate and extent of colon absorption are important determinants of the in vivo performance of extended-release (ER) drug products.
![ADME characterization and PBK model development of 3 highly protein-bound UV filters through topical application](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
ADME characterization and PBK model development of 3 highly protein-bound UV filters through topical application
Estimating human exposure in the safety assessment of chemicals is crucial. Physiologically based kinetic (PBK) models which combine information on exposure, physiology...
![FIH Simulator Comparison](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
FIH Simulator Comparison
Fully power your first in human predictions.
![Concierge+ Flyer](https://www.simulations-plus.com/wp-content/uploads/Concierge-Flyer-1200x1080.jpg)
Concierge+ Flyer
Drug development is a long and winding road, but we can help you navigate it.
![Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330](https://www.simulations-plus.com/wp-content/uploads/Bridging-APX3330-1-1200x1080.jpg)
Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330
APX3330 ((2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid), a selective inhibitor of APE1/Ref-1, has been investigated in treatment of hepatitis, cancer, diabetic retinopathy, and macular edema.
![In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis](https://www.simulations-plus.com/wp-content/uploads/In-vitro-fibrosis-1-1200x1080.jpg)
In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that affects lysosome-related organelles, often leading to fatal pulmonary fibrosis (PF)
![Simulations Plus Reports Fourth Quarter Fiscal 2023 Financial Results](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Reports Fourth Quarter Fiscal 2023 Financial Results
Fiscal 2023 revenue increased 11% year-over-year to $59.6 million
Provides Fiscal 2024 revenue guidance of $66 - $69 million (+10-15%) and EPS guidance of $0.66 - $0.68
Simulations Plus to host its Investor Day on November 14, 2023
![Refining Predictions of Food Effects on Drug Absorption: Models Predicting Gastric Emptying and Bile Concentrations Based on Fat Content and Caloric Intake](https://www.simulations-plus.com/wp-content/uploads/R-I-1200x1080.jpg)
Refining Predictions of Food Effects on Drug Absorption: Models Predicting Gastric Emptying and Bile Concentrations Based on Fat Content and Caloric Intake
In the realm of pharmaceutical R&D, the quest for enhanced predictive accuracy and efficiency for Fed State PBPK models has never been more pressing.