Orforglipron Weight Loss and Nausea Accurately Simulated with OBESITYsym

Authors: C Vallejo, Kenz Z, Siler SQ
Conference: AAPS
Keywords: AAPS2024, clinical data, nausea, obese, OBESITYsym, QSP (quantitative systems pharmacology)
Division: Quantitative Systems Pharmacology (QSP)

Purpose

  • The recent availability of effective, GLP-1R agonist (GLP-1RA) based treatments of obesity has provided great benefit to patients
  • Understanding the balance between body weight (BW) loss and nausea is paramount in predicting the effectiveness of oral GLP-1RA based medications
  • Quantitative systems pharmacology (QSP) modeling can aid in predicting both efficacy and adverse events of compounds, particularly when clinical data are available

By Celeste Vallejo, Zackary Kenz, and Scott Q Siler

American Association of Pharmaceutical Scientists (AAPS) PharmSci 360, October 20-23, 2024, Salt Lake City, Utah