Featured Webinar Replay:
Dr. Marv Waldman walks you through the AIDD™ module – the most highly-automated customizable protocol commercially available!
WATCH HERE
Featured “How-To” Videos:
LEARN MORE WITH MAXIME
ACoP Conference Nov.9 – 13, 2020
Posters Presentations:
- Comparison of pharmacokinetics and QTc effect of Quizartinib in Japanese and non-Japanese patients with Relapsed/Refractory (R/R) FLT3-ITD positive acute myeloid leukemia (AML) using population pharmacokinetic (PopPK) analyses
- Development of Quantitative Systems Toxicology Model to Predict Drug Induced Acute Kidney Injury via mtDNA Depletion Pathway
- Modeling Insights on Species Differences in Response to CD8+ T cell-mediated Liver Injury
- Representation of Efavirenz-mediated Drug-Induced Liver Injury (DILI) Using Quantitative Systems Toxicology (QST)
- Mathematically modeling CD8+ T cell-mediated drug-induced liver injury (DILI): from ovalbumin (OVA) to amodiaquine in mice
- Quantitative Systems Toxicology Modeling Supports Safety Determination for Ubrogepant, a Novel CGRP Inhibitor
- Mechanistic Modeling of Cyclosporine A-induced Acute Kidney Injury with RENAsym™
- A library of tumor growth and tumor growth inhibition models for the MonolixSuite
- Simulation of first-in-human using an allometrically scaled population mechanistic TMDD model with preclinical monkey data
- Implementation of the C-QTc study using MonolixSuite applications
- GUI: a flexible and user-friendly application for simulations
Aksana Jones, Arlene Padron, Beth Ludwig, Christian Claussen, Cherylann Iagatta, Claude Magnard, Géraldine Ayral, Grace Fraczkiewicz, Hannah Huang, Jill Fiedler-Kelly, Joel Owen, Jonathan Chauvin, Julie Passarell, Kevin Dykstra, Monika Twarogowska, Pauline Traynard, Sebastien Bihorel, and Yogesh Patel.
AAPS Conference Nov. 2 – 5, 2020
Rapid Fire Sessions:
Tuesday, Nov. 3, 9-9:45 AM EST
Clinical Pharmacology Driving Innovative Trial Design
Kevin Dykstra – Vice President, Consulting Services
Wednesday, Nov. 4, 4–4:15 PM EST
Hepatotoxicity of Compound V Evaluated with Quantitative Systems Toxicology
Vinal V. Lakhani – Scientist I
PharmSci360 posters:
- *Best Abstract Award Winners: PBBM Analysis of the In Vivo Behavior of Amorphous Solid Dispersions Based on Water-Soluble versus Water-Insoluble Carriers: A Fenofibrate Case Study
- *Best Abstract Award Winner: Physiologically Based Pharmacokinetic Modeling of Oxybate: The Role of Counter-ions in Gastrointestinal Absorption
- Physiologically-Based Pharmacokinetic Model to Describe the Pharmacokinetics of Crushed Morphine Sulfate and Naltrexone Hydrochloride Extended-Release Capsules with Abuse Deterrent Properties
- Modeling the Impact of Amorphous Drug-Polymer Colloids on the Absorption of Poorly Water Soluble Drugs
- Pharmacokinetic Profile and Physiologically Based Pharmacokinetic Modeling of Matrine in Healthy Human Plasma and Saliva
- Quantitative Systems Toxicology Identifies the Mechanism and Data Gaps for Evaluating the Hepatotoxicity of Compound V
- Quantitative Systems Toxicology (DILIsym) Modeling of the Acetaminophen (Paracetamol) Mode of Action (MOA) Pathway for Hepatotoxicity Supports that Acetaminophen Is Not a Carcinogenic Hazard in Humans
- Quantitative Systems Toxicology Modeling Using DILIsym Suggests That Drug-Induced Liver Injury Can Be Enhanced by Co-administered Drugs and Mitigated by Mitochondrial Biogenesis
- Application of Minimal Physiologically Based Pharmacokinetic Model for Insulin: A Population Analysis
- Hybrid CFD-PBPK Model for Prediction of Systemic PK Following Nasal Insufflation of Milled Oxycodone Hydrochloride Extended-Release Tablets
- Applying Computational Prediction of Biorelevant Solubility in Dispersions of Self-Emulsifying Lipid-Based Formulations to Predict Dose Number
Drop a Business Card & Schedule a Meeting in booth VB1921 (click here) co-hosted by:
Arlene Padron, Brett Howell, Dan O’Connor, Cherylann Iagatta, Eric Jamois, Grace Fraczkiewicz, James Mullin, Jasmina Novakovic, Joel Owen, Ke Szeto, Kyunghee Yang, Michael Bolger, Sandra Suarez-Sharp, and William van Osdol.
Now Available for Download
APX – Powerful ADMET Property Estimation, at your fingertips!
GastroPlus v9.8 – Confirm much more than your “gut instinct” with enhancements to all validated non-oral delivery route models!
MonolixSuite – Take your modeling and simulation to the next level!
Academic/Reference Site License Opportunities
Simulations Plus offers special academic pricing and licensing options for accredited institutions.
- DILIsym Teaching License
- DILIsym Research License
- Lixoft Academic License
- Simulations Plus Reference Site License
Copyright © 2021 Simulations Plus, All rights reserved.
Simulations Plus Monthly News & Events
Simulations Plus, Inc.:
42505 10th Street West
Lancaster, CA 93534
Telephone: +1-661-723-7723
Cognigen Corporation, a Simulations Plus company:
1780 Wehrle Drive, Suite 110
Buffalo, NY 14221-7000
Telephone: +1-716-633-3463
DILIsym Services, a Simulations Plus company:
Six Davis Drive
PO Box 12317
Research Triangle Park, NC 27709
Telephone: +1-919-558-1323
Lixoft, a Simulations Plus company
8 rue de la Renaissance Batiment D
92160 Antony, France
Telephone: +33 9 72 53 91 80