Modeling and Simulation of the Local Tissue Response to the Long-acting Injectable Formulations

Authors: Shahraz A, Mullin JM, Lukacova V
Conference: ACoP
Keywords: drug exposure, immune, inflammation, local tissue response, long-acting injectable formulations
Software: GastroPlus®
Division: PBPK

Objectives

Recently, long-acting injectable (LAI) drug formulations have attracted much attention for prolonged drug exposure from weeks to several months. However, the administration of foreign materials in the tissue can result in a variety of injection site reactions (ISRs), which have not been well characterized in the literature. The focus of the present work is to model consequences of localized chronic inflammation in tissue on drug diffusion and exposure caused by prolonged therapy with long-acting formulations.

Tenth American Conference on Pharmacometrics (ACoP) Annual Meeting, October 19-22, 2019, Orlando, FL

By Azar Shahraz, James Mullin, Viera Lukacova