Introduction

Wagner-Nelson,  Loo-Riegelman,  numerical  deconvolution,  and  convolution-based  methods  are conventional ways to form an in vitro-in vivo correlation (IVIVC). The ultimate goal for forming an IVIVC is to develop a correlation or relationship between the in vitro release and in vivo release of a formulation so that an in vivo release profile can be predicted from a given in vitro release profile. The Wagner-Nelson and Loo-Riegelman methods form a correlation between in vitro release and bioavailability, which is not truly representative of a correlation between in vitro release and in vivo release, because bioavailability is affected by a combination of factors such as in vivo release, precipitation, permeability (carrier-mediated and passive transport), and first pass metabolism. Numerical deconvolution and convolution-based methods can be used to develop a correlation between in  vitro  release and  in  vivo  release;  however, these  methods  require the assumption of linear kinetics, which may not be appropriate for drugs that exhibit nonlinear pharmacokinetics.

American Association of Pharmaceutical Scientists (AAPS), November 17-19, 2008, Atlanta, GA

By John I. Chung, Viera Lukacova, John R. Crison, Michael B. Bolger, & Walter S. Woltosz