Influence of Dose Size on Dose Response Relationships for Linezolid Efficacy Using Monte Carlo Simulations

Authors: Cirincione B, Grasela TH, Caito K, Antal E, Hafkin B, Bruss J
Conference: AAPS
Keywords: adult, antibiotic, AUC:MIC ratio, cure rate, logistic regression, methicillin-resistant Staphylococcus aureus, MIC, minimum inhibitory concentration, MRSA, PD, pharmacodynamic, simulation, steady state
Division: Clinical Pharmacology and Pharmacometrics (CPP)

ABSTRACT

Purpose. Phase II linezolid (LZD) data analyses suggested that AUC0-24/MIC ratio was an important predictor of efficacy outcome. Monte Carlo simulations were performed to determine whether dose size influences both the proportion of patients with MRSA at risk for suboptimal AUC/MIC ratios when administered LZD 500 or 600 mg BID regimens and the expected cure rates.

American Association of Pharmaceutical Scientists (AAPS); Indianapolis, Indiana; October 2000

By B. Cirincione, Thaddeus H. Grasela, K. Caito, Elizabeth Ludwig, E. Antal, B. Hafkin, J. Bruss