In Vitro and In Vivo Pharmacokinetic Characterization of 7-Hydroxymitragynine, an Active Metabolite of Mitragynine, in Sprague-Dawley Rats

Authors: Chiang YH, Kanumuri SRR, Kuntz MA, Senetra AS, Berthold EC, Kamble SH, Mukhopadhyay S, Hampson AJ, McCurdy CR, Sharma A
Publication: Eur J Drug Metab Pharmacokinet
Keywords: admet predictor, In silico pharmacokinetic (PK) simulations, in vitro, in vivo
Software: ADMET Predictor®
Division: Cheminformatics

Background and Objectives

Kratom, a Southeast Asian tree, has been researched for its potential as a therapeutic for substance use disorders. The most abundant alkaloid in kratom, mitragynine, is being investigated individually for opioid use disorder. However, the active metabolite of mitragynine,7-hydroxymitragynine (7-HMG) has raised concerns because of its high binding affinity to μ-opioid receptors and abuse potential. This study examines various pharmacokinetic parameters of 7-HMG in both in vitro and in vivo models.

By Yi-Hua Chiang, Siva Rama Raju Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Erin C. Berthold, Shyam H. Kamble, Sushobhan Mukhopadhyay, Aidan J. Hampson, Christopher R. McCurdy & Abhisheak Sharma