With a new interface, updated workflows, and advanced features, it may be challenging to know how to get started with GastroPlus(R) X. That’s why our experts developed a video tutorial series to help you begin.
Follow along as each tutorial dives into essential features and functionalities of GPX.
Getting Started
If you have never used GPX or had the chance to see a demo, you’ll want to get an overview of the platform. In this video, you’ll see the new user-friendly interface that delivers the industry-leading PBPK/PBBM predictions our customers count on.
Watch this tutorial for an introduction to the new GPX paradigm.
If you have legacy databases, you don’t need to start over and rebuild them in GPX. In this video installment, you’ll learn how to import your database so you can continue working on your model.
Learn how to import a GastroPlus database into GPX and rearrange the imported data in this tutorial.
What if you could create a project, run multiple simulations, and compare them on the same graph in a matter of minutes? Now you can.
Learn how you can create a project from scratch in this tutorial.
In this video, you’ll learn how to use GPX to rapidly evaluate different dosing scenarios with simplified, reusable dosing schedules.
Learn how to set up different types of dosing schedules.
The Physiologies and Physiology Schedules functionality in GPX makes it easy to model changes in physiology with time, like food status, age, weight, or health status.
Learn how to work with Physiologies and Physiology Schedules in the tutorial.
Get in silico properties (e.g. pKa, permeability, solubility, CYP metabolism kinetics and more) by performing an import of your compound chemical structure with ADMET Predictor®!
Find out how to import a chemical structure via the ADMET Predictor module.
Learn how to include multiple solubilities (forms) for a compound in your model–GPX allows as many solubilities as you need!
In addition to the individual simulations, GPX allows you to run batch simulations, as well as optimization, parameter sensitivity analysis, population simulation and virtual bioequivalence. We broke down the various run modes in GPX into a 3-part miniseries.
Watch part 1 to learn about the run modes (batch) simulation and optimization.
Watch part 2 to learn about the run modes for parameter sensitivity analysis.
Watch part 3 to learn run modes for population simulation and virtual bioequivalence.
Develop your PBPK model in a number of species with perfusion-limited and/or permeability-limited tissues, and quickly add/delete tissues as needed–all without writing any equations!
Find out what input parameters and PBPK settings you should use in this tutorial.
Convert in vitro kinetic parameters to in vivo kinetic parameters through assay-specific scaling and incorporate Michaelis-Menten Kinetics and linear clearance into your model.
Did you know GPX can predict the interactions that might occur when multiple medications are taken simultaneously, with no restriction on the number of compounds?
Learn about the drug-drug interaction (DDI) module in GPX in this tutorial.
Exporting compartmental and non-compartmental PK analysis is as simple as toggling on a feature in GPX.
Learn more about the PKPlus module in GPX in this tutorial.
In addition to classical deconvolution techniques (numerical, Wagner-Nelson, Loo-Riegelman), did you know GastroPlus was the first software program to offer “mechanistic deconvolutions,” to be able to build a mechanistic IVIVC?
Learn more about the IVIVC module in GPX.
Building PBPK/PD models is no problem in GPX.
Learn about the PDPlus module in GPX in this tutorial.
There’s no need to recreate all your assets for each project. GPX allows you to export and import them in new projects.
This tutorial shows you how to export and import from current projects to new ones
The ACAT module in GPX helps predict how drugs are behaving in the gastrointestinal tract with regards to dissolution, precipitation and absorption. This part is crucial to build an accurate model for orally administered drugs.
Watch this tutorial to learn about the ACAT module in GPX.
Did you know that if you don’t want to go fully mechanistic, simplified absorption models are now available in GPX?
Learn about the simplified absorption and pharmacokinetics models in GPX.
Create high-level summaries and deep-diving views of your predictions with GPX.
In this tutorial you’ll learn about the reporting outputs in GPX.
The new Lab Book in GPX enables you to track all your work, for easy retrieval and easier communication across teams.
Learn about the new Lab book in GPX in this five-minute tutorial.
Finally, this tutorial will go through the optimal and most efficient way for you to take a project from GPX and recreate it in the legacy GastroPlus to validate your results.
Continue Your Learning Journey
If you’ve completed this tutorial series, you understand the power of GPX and its range of capabilities. But if you’re interested in diving deeper, check out our on-demand courses, where you can learn at your own pace.