Gatifloxacin Exposure in Maxillary Sinus and Middle Ear – All Sites of Infection Are Not Created Equal

Authors: Rubino CM, Ambrose PG, Bhavnani SM, Webb CD, Anon JB
Conference: IDSA
Keywords: adult, anti-infectives, antibiotic, effect compartment model, infectious disease, middle ear, NONMEM, otitis media, Otolaryngology, pediatrics, pharmacokinetic, PK, sinusitis
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Abstract

Background: Due to the similar physiology of maxillary sinus (MS) and middle ear (ME), it is often assumed that antimicrobial penetration is similar into MS and ME fluids. Traditional methods for assessing drug penetration into these closed compartments (single point estimates of concentration ratio) often support this assumption. Here, we present results from two analyses, each comparing drug exposure in a closed infection space with that in plasma.

Infectious Diseases Society of America (IDSA); San Diego, California; October 2003

By Christopher M. Rubino, Paul G. Ambrose, Sujata M. Bhavnani, C. D. Webb, and Jack B. Anon