Development of Silica Release Model for Intraocular Injections

Authors: Mullin JM
Conference: CRS
Keywords: Drug dissolution, intraocular injections, silica release model
Software: DDDPlus™
Division: PBPK

Introduction

This poster reviews the development of a numerical framework within DDDPlus™ (Version 6.0, Simulations Plus, Inc.) to simulate the degradation and drug dissolution/release from silica matrix formulations within a flow-through apparatus that simulates physiologically relevant flow and volume of the vitreous. The proposed mathematical model is then used to describe the degradation of silica particles as well as drug release from vancomycin and bupivacaine.

By James Mullin

CRS Annual Meeting & Expo: “The Future of Delivery Science” July 24th – 28th, 2023