Applying in silico-in vitro-in vivo extrapolation (IS-IVIVE) techniques to predict exposure and guide risk assessment

Authors: DiBella J, Howell BA
Conference: SOT
Keywords: clinical trial, exposure, In vitro in vivo extrapolation (IVIVE), liver safety, PBPK modeling, Quantitative Systems Toxicology (QST), risk assessment
Software: ADMET Predictor®, DILIsym®, GastroPlus®
Division: PBPK, Quantitative Systems Pharmacology (QSP)

Summary

  • Combining QSAR, PBPK, and QST models is a powerful approach to getting more information out of your data investments early in product development
  • The Simulations Plus family has extensive experience with these approaches and can help
  • ADMET Predictor / GastroPlus / DILIsym is a winning software package combination for predicting the liver safety of your molecules and those of your competitors prior to clinical trial surprises

SOT 57th Annual Meeting and ToxExpo, March 11-15, 2018, San Antonio, Texas

By John DiBella, Brett Howell