Absorption Predictions: Current Capabilities and Knowing the Gaps

Authors: Lukacova V
Conference: ISSX
Keywords: Advanced Compartmental Absorption Transit (ACAT) model, dissolution, in vivo, mechanistic absorption models (MAM), oral absorption, solubility
Software: ADMET Predictor®, GastroPlus®
Division: PBPK

Summary

  • Number of different processes contribute to net drug absorption
  • Different in vitro assays are available to determine input parameters for individual processes
  • Mechanistic simulations of in vitro assays are an important tool to ‘deconvolute’ parameter values and aid in in vitro – in vivo
    extrapolation

    • Accuracy of in vitro – in vivo extrapolation varies between the processes
  • To predict the overall in vivo absorption, the interplay of all relevant processes needs to be considered

By Viera Lukacova

Presented at ISSX/MDO 2022, September 11-14, 2022, Seattle, WA