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PK-PD Evaluation of Doripenem (DOR) Against Extended Spectrum ß-Lactamase (ESBL) Producing Enterobacteraceae

PK-PD Evaluation of Doripenem (DOR) Against Extended Spectrum ß-Lactamase (ESBL) Producing Enterobacteraceae

Authors: Andes D, Craig WA, Bhavnani SM, Jones RN, Thye D, Wikler MA, Ambrose PG
Conference: IDSA
Keywords: anti-infectives, antibiotic, bacilli, carbapenem, cefepime, ceftazidime, E coli, Emax, enterobacter, gram-negative, infectious disease, intravenous, IV, Klebsiella, MIC, mice, Monte Carlo, murine, pseudomonas, SC, simulation, subcutaneous, T>MIC
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Increasing resistance among ESBL-producing bacteria is a growing concern. We examined the potential utility of DORI against ESBL-producing isolates.