Integrating Human Biomimetic Liver Microphysiology System with Quantitative Systems Toxicology Modeling to Predict DILI
![Integrating Human Biomimetic Liver Microphysiology System with Quantitative Systems Toxicology Modeling to Predict DILI](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Integrating Human Biomimetic Liver Microphysiology System with Quantitative Systems Toxicology Modeling to Predict DILI
Integrating Human Biomimetic Liver Microphysiology System with Quantitative Systems Toxicology Modeling to Predict DILI
![Construction of a Simulated Population of Post-Menopausal Women for the Prediction of Drug-Induced Liver Injury (DILI)](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Construction of a Simulated Population of Post-Menopausal Women for the Prediction of Drug-Induced Liver Injury (DILI)
ASCPT 2024: Construction of a Simulated Population of Post-Menopausal Women for the Prediction of Drug-Induced Liver Injury (DILI)
![Lunch & Learn – SOT 63rd Annual Meeting and ToxExpo](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Lunch & Learn – SOT 63rd Annual Meeting and ToxExpo
SOT 2024: What's New at Simulations Plus, Your Partner in Winning, for Exposure and Safety Assessment
![Simulations Plus Investor Day 2023](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Investor Day 2023
Putting Clients First Drives Growth and Fuels Innovation
![Contributed data, collaboration and experience with ionization models – Part 1. Bayer Pharmaceuticals](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Contributed data, collaboration and experience with ionization models – Part 1. Bayer Pharmaceuticals
World‘s best in class pKa prediction tool
![Utilizing pKa Values for Effective Crop Protection: On Systemicity and Efficacy of Molecules](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Utilizing pKa Values for Effective Crop Protection: On Systemicity and Efficacy of Molecules
pKa important factor in research screening cascade of molecules
![Improving pKa modelling through active collaborations](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Improving pKa modelling through active collaborations
What needs to be completed for collaboration?
![Impact of collaborative pKa modelling](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Impact of collaborative pKa modelling
Importance of pKa in Drug Discovery
![The application of AI-driven Drug Discovery technology for molecular optimization of nuclear receptor ligands](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
The application of AI-driven Drug Discovery technology for molecular optimization of nuclear receptor ligands
ADMET Predictor® as a de novo drug design environment
![Applying Mechanistic PBPK Modeling and Simulations to Support Regulatory Interactions](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Applying Mechanistic PBPK Modeling and Simulations to Support Regulatory Interactions
Physiologically-Based Pharmacokinetic (PBPK) Modeling is a Tool/Component of Model-Informed Drug Development (MIDD)
![Model conception, parameterization using in silicomethods, and computational implementation](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Model conception, parameterization using in silicomethods, and computational implementation
The PKB model structure depends on the problem, knowledge of the biokinetic mechanism, and availability of suitable data
![Application of Modeling and Simulation in Long-Acting Injectable Product Development](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Application of Modeling and Simulation in Long-Acting Injectable Product Development
Discuss advances in mechanistic models to simulate in vitro and in vivobehavior of long acting injectables.
![From Preclinical to Clinical Drug Product Development: A Path for Smooth Transition](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
From Preclinical to Clinical Drug Product Development: A Path for Smooth Transition
It is challenging to establish a standard approach for moving from preclinical to clinical phases of development. Many hurdles exist during formulation selection and for extrapolation of doses from animals to humans; what may have worked well for one drug candidate may not be appropriate for others. This presentation will provide a general framework/strategy to follow when moving from preclinical to clinical studies (FIH) based on risk identification and mitigation focusing on the application of mechanistic modeling and simulation (PBPK).
![Absorption Predictions: Current Capabilities and Knowing the Gaps](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Absorption Predictions: Current Capabilities and Knowing the Gaps
Number of different processes contribute to net drug absorption
![Complex Delivery Routes and Generics: The Next Frontier for PBBM/PBPK Modeling](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Complex Delivery Routes and Generics: The Next Frontier for PBBM/PBPK Modeling
Generic drug development for locally acting drug products is a fast-growing field of interest
![Data required to build a fit-for-purpose PBPK model: How much is necessary?](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Data required to build a fit-for-purpose PBPK model: How much is necessary?
PBPK/PBBM model development can be initiated at any stage of product development
![Predictive Dissolution Modeling with Clinically Relevant Specifications](https://www.simulations-plus.com/wp-content/uploads/Predictive-Dissolution-Modeling-with-Clinically-1200x1080.jpg)
Predictive Dissolution Modeling with Clinically Relevant Specifications
The role of biopharmaceutics risk assessment
![Simulations Plus General Overview](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus General Overview
Our solutions inform the entire drug development process