
Simulations Plus Renews Important Global Software License
Large Customer Renews Annual Global License for GastoPlus ™

Simulations Plus Announces Conference Call Details
Call To Be Held On Tuesday, December 13, at 4:30 PM EST

Simulations Plus Releases GastroPlus TM Version 5.0
Completion of Two-Year Development Program Adds Major New Functionalities

Simulations Plus Requests Extension for 10K-SB Filing
Company Plans Conference Call Shortly After Release

Simulations Plus Announces Change in Investor Relations
Function to be Moved In-House for Greater Operating Efficiency

Simulations Plus Announces Release of New Toxicity Prediction for ADMET Predictor™
hERG Potassium Channel Blocking Affinity Models Important Cardiac Toxicity

Simulations Plus Expands Field Sales Force
Product Manager to Become Full-time Field Representative

Simulations Plus Acquires Assets of Sage Informatics LLC
New Product Line and Key Employee Expand Software Offerings and Science Staff

Simulations Plus Subsidiary, Words+, Inc., Terminates Royalty and Support Agreement with Sam Communications, LLC
Termination by Mutual Agreement to Result in Reduced Expenses

Simulations Plus Announces Release of ADMET Modeler™ 1.0 and Upgrade of ADMET Predictor™
Name change, new features, compatibility with ADMET Predictor™

Simulations Plus Announces Release of DDDPlus™ 1.0
New core product is first in industry

Simulations Plus Announces Release of ADMET Predictor™ 1.0
Name change, new features, and new pricing expected to boost sales

Simulations Plus Reports Results for First Fiscal Quarter of Fiscal Year 2004
Record 1st Quarter Revenues and 8th Consecutive Profitable Quarter

Simulations Plus (“SLP”) Releases DDDPlus 4.0
One-of-a-Kind Product Gets Important New Capabilities