Pseudomonas aeruginosa is one of the more common and clinically difficult-to-treat causes of hospital-acquired infections.

Pharmacodynamics in the evaluation of drug regimens
We believe, especially in an era of increasing antimicrobial resistance, that the integration of PK/PD models and stochastic techniques provides a powerful new tool...

Pharmacodynamic profiling of levofloxacin and gatifloxacin using Monte Carlo simulation for community-acquired isolates of Streptococcus pneumoniae
In vitro and in vivo models of infection suggest that the area under the concentration-time curve (AUC): minimum inhibitory concentration (MIC) ratio...

A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide
Pharmacokinetic (PK) and pharmacodynamic (PD) models for azimilide were developed and validated with sparse blood sampling and QTc interval data obtained

Pharmacodynamics of fluoroquinolones against Streptococcus pneumoniae in patients with community-acquired respiratory tract infections
Fluoroquinolone antibiotic agents have demonstrated efficacy in the treatment of respiratory tract infections.

Implementation of a nursing home urinary incontinence management program with and without tolterodine
To evaluate the implementation of a nursing home urinary incontinence management program.

Predicting the impact of physiological and biochemical processes on oral drug bioavailability
Recent advances in computational methods applied to the fields of drug delivery and biopharmaceutics will be reviewed with a focus on prediction of the impact of physiological and biochemical factors on...

Ties in Proximity and Clustering Compounds
Hierarchical clustering algorithms such as Wards or complete-link are commonly used in compound selection and diversity analysis. Many such applications utilize binary representations of chemical structures...

Percolation Theory : Applications In Pharmacy
Percolation theory is a statistical theory applied to explain behaviour of disordered systems.

Results of a new classification algorithm combining K nearest neighbors and recursive partitioning
We present results of a new computational learning algorithm combining favorable elements of two well-known techniques: K nearest neighbors and recursive partitioning.

Androgen receptor antagonists (antiandrogens): structure-activity relationships
Prostate cancer, acne, seborrhea, hirsutism, and androgenic alopecia are well recognized to depend upon an excess or increased sensitivity to androgens...

Characterization of the highly variable bioavailability of tiludronate in normal volunteers using population pharmacokinetic methodologies
Currently, the use of classical bioequivalence criteria is being called into question for certain classes of drugs such as bisphosphonates. These compounds typically possess a wide therapeutic index but may...

Applying epidemiology-based outcomes research to clinical decision-making A hypothetical model of biotechnology therapy in gram-negative sepsis
Sepsis occurs in a heterogeneous population. A prospective nationwide surveillance study found that populations stratified by infection type had significant differences in the incidence...

Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage
Data collected during Phase I and II in the development of tirilazad were pooled and analyzed using nonlinear mixed effects models to assess covariates which might affect tirilazad pharmacokinetics.

Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy
Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled

An automated drug concentration screening and quality assurance program for clinical trials
The collection and analysis of drug concentration data collected during clinical trials is growing in popularity as a mechanism for explaining variability in patient outcomes.

Relationship between didanosine exposure and surrogate marker response in human immunodeficiency virus-infected outpatients
We used information available from routine clinic visits to characterize the pharmacokinetics of didanosine in 82 human immunodeficiency virus-infected patients.

Zalcitabine population pharmacokinetics: application of radioimmunoassay
Zalcitabine population pharmacokinetics were evaluated in 44 human immunodeficiency virus-infected patients (39 males and 5 females) in our immunodeficiency clinic.

Dose proportionality of cisatracurium
The dose proportionality of cisatracurium pharmacokinetics was assessed using a population approach by incorporating the collection of sparse...

Pharmacoepidemiology: a scientific basis for outcomes research
The discovery of fossils estimated to be about 550 million years old' and later, the interpretation of these fossils, forced a rethinking