Pharmacodynamics in the evaluation of drug regimens

Pharmacodynamics in the evaluation of drug regimens

Publication: Ann Pharmacother

We believe, especially in an era of increasing antimicrobial resistance, that the integration of PK/PD models and stochastic techniques provides a powerful new tool...

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Publication: Adv Drug Deliv Rev
Software: GastroPlus®
Division: PBPK

Recent advances in computational methods applied to the fields of drug delivery and biopharmaceutics will be reviewed with a focus on prediction of the impact of physiological and biochemical factors on...

Ties in Proximity and Clustering Compounds

Ties in Proximity and Clustering Compounds

Publication: J Chem Inf Model
Software: MedChem Studio™

Hierarchical clustering algorithms such as Wards or complete-link are commonly used in compound selection and diversity analysis. Many such applications utilize binary representations of chemical structures...

Results of a new classification algorithm combining K nearest neighbors and recursive partitioning

Results of a new classification algorithm combining K nearest neighbors and recursive partitioning

Authors: Miller DW
Publication: J Chem Inf Model
Software: MedChem Studio™

We present results of a new computational learning algorithm combining favorable elements of two well-known techniques:  K nearest neighbors and recursive partitioning.

Characterization of the highly variable bioavailability of tiludronate in normal volunteers using population pharmacokinetic methodologies

Characterization of the highly variable bioavailability of tiludronate in normal volunteers using population pharmacokinetic methodologies

Publication: Eur J Drug Metab Pharmacokinet

Currently, the use of classical bioequivalence criteria is being called into question for certain classes of drugs such as bisphosphonates. These compounds typically possess a wide therapeutic index but may...

Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage

Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage

Publication: Pharm Res

Data collected during Phase I and II in the development of tirilazad were pooled and analyzed using nonlinear mixed effects models to assess covariates which might affect tirilazad pharmacokinetics.

Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy

Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy

Publication: J Clin Pharmacol

Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled

An automated drug concentration screening and quality assurance program for clinical trials

An automated drug concentration screening and quality assurance program for clinical trials

Publication: Drug Inf J

The collection and analysis of drug concentration data collected during clinical trials is growing in popularity as a mechanism for explaining variability in patient outcomes.

Zalcitabine population pharmacokinetics: application of radioimmunoassay

Zalcitabine population pharmacokinetics: application of radioimmunoassay

Publication: Antimicrob Agents Chemother

Zalcitabine population pharmacokinetics were evaluated in 44 human immunodeficiency virus-infected patients (39 males and 5 females) in our immunodeficiency clinic.

Dose proportionality of cisatracurium

Dose proportionality of cisatracurium

Publication: Pharm Res

The dose proportionality of cisatracurium pharmacokinetics was assessed using a population approach by incorporating the collection of sparse...