Relationships between patient and institution specific variables and decreased antimicrobial susceptibility of gram-negative pathogens

Relationships between patient and institution specific variables and decreased antimicrobial susceptibility of gram-negative pathogens

Publication: Clin Infect Dis

The identification of patients infected with antibiotic-resistant strains of bacteria for inclusion in clinical trials remains a serious challenge for the future development of agents for use against such infections.

Composite solubility versus pH profile and its role in intestinal absorption prediction

Composite solubility versus pH profile and its role in intestinal absorption prediction

Publication: AAPS PharmSci
Software: GastroPlus®
Division: PBPK

The purpose of this study was to examine absorption of basic drugs as a function of the composite solubility curve and intestinally relevant pH by using a gastrointestinal tract (GIT) absorption...

Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in vivo

Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in vivo

Authors: Jones JO, Arvin AM
Publication: J Virol
Division: PBPK

During primary infection, varicella-zoster virus (VZV) is spread via lymphocytes to skin, where it induces a rash and establishes latency in sensory ganglia.

Rule Extraction from a Mutagenicity Data Set Using Adaptively Grown Phylogenetic-like Trees

Rule Extraction from a Mutagenicity Data Set Using Adaptively Grown Phylogenetic-like Trees

Publication: J Chem Inf Model
Software: MedChem Studio™

A public bacterial mutagenicity database was classified into 2-D structural families using a set of specific algorithms and clustering techniques that find overlapping...

Data Analysis of High-Throughput Screening Results:  Application of Multidomain Clustering to the NCI Anti-HIV Data Set

Data Analysis of High-Throughput Screening Results:  Application of Multidomain Clustering to the NCI Anti-HIV Data Set

Publication: J Med Chem
Software: MedChem Studio™

The routine use of high-throughput screening (HTS) systems in the drug discovery process has resulted in an increasing need for fast, reliable analysis of massive amounts of data.

Rapid Assessment of Data Set Structures

Rapid Assessment of Data Set Structures

Authors: Vecchione P
Conference: Pharmaceutical Industry SAS Users Group (PharmaSUG)

When SAS® data is received from an external source, such as a sponsor, CRO, or another department, it is important to assess the new data to determine if variables have been added or removed, locate…