We present results of a new computational learning algorithm combining favorable elements of two well-known techniques: K nearest neighbors and recursive partitioning.
Androgen receptor antagonists (antiandrogens): structure-activity relationships
Prostate cancer, acne, seborrhea, hirsutism, and androgenic alopecia are well recognized to depend upon an excess or increased sensitivity to androgens...
Characterization of the highly variable bioavailability of tiludronate in normal volunteers using population pharmacokinetic methodologies
Currently, the use of classical bioequivalence criteria is being called into question for certain classes of drugs such as bisphosphonates. These compounds typically possess a wide therapeutic index but may...
Applying epidemiology-based outcomes research to clinical decision-making A hypothetical model of biotechnology therapy in gram-negative sepsis
Sepsis occurs in a heterogeneous population. A prospective nationwide surveillance study found that populations stratified by infection type had significant differences in the incidence...
Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage
Data collected during Phase I and II in the development of tirilazad were pooled and analyzed using nonlinear mixed effects models to assess covariates which might affect tirilazad pharmacokinetics.
Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy
Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled
An automated drug concentration screening and quality assurance program for clinical trials
The collection and analysis of drug concentration data collected during clinical trials is growing in popularity as a mechanism for explaining variability in patient outcomes.
Relationship between didanosine exposure and surrogate marker response in human immunodeficiency virus-infected outpatients
We used information available from routine clinic visits to characterize the pharmacokinetics of didanosine in 82 human immunodeficiency virus-infected patients.
Zalcitabine population pharmacokinetics: application of radioimmunoassay
Zalcitabine population pharmacokinetics were evaluated in 44 human immunodeficiency virus-infected patients (39 males and 5 females) in our immunodeficiency clinic.
Dose proportionality of cisatracurium
The dose proportionality of cisatracurium pharmacokinetics was assessed using a population approach by incorporating the collection of sparse...
Pharmacoepidemiology: a scientific basis for outcomes research
The discovery of fossils estimated to be about 550 million years old' and later, the interpretation of these fossils, forced a rethinking
Pretreatment regimens for adverse events related to infusion of amphotericin B
Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often lead clinicians to prescribe a number of adjunctive pretreatment medications...
Adverse drug reaction reporting in a multicenter surveillance study
To evaluate the performance of a multicenter, prospective surveillance program in identifying adverse events, and to seek explanations for misclassification bias.
Sepsis syndrome and associated sequelae in patients at high risk for gram negative sepsis
We conducted a prospective surveillance study of 80 hospitals across the United States to determine the incidence of sepsis syndrome and its associated sequelae in hospitalized patients over age 18 years who...
Analysis of potential risk factors associated with the development of pancreatitis in phase I patients with AIDS or AIDS related complex receiving didanosine
Phase I dose-escalating trials of didanosine revealed dose-limiting toxicities, including pancreatitis, and established a total daily dose of 12.5 mg/kg/day as the maximum tolerated dose.
Risk factors for acute renal insufficiency in patients with suspected or documented bacterial pneumonia
To describe the incidence of acute renal insufficiency and identify potential risk factors associated with this adverse medical event.
Use of antifungal therapy in hospitalized patients. II. Results after the marketing of fluconazole
To evaluate the prescribing patterns of antifungal agents in the hospital setting after the introduction of fluconazole, a new broad-spectrum bis-triazole antifungal agent.
Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia
During propofol-nitrous oxide (N2O) anesthesia, volatile anesthetics are frequently administered to treat signs of inadequate anesthesia and to decrease the possibility of intraoperative awareness.
The role of pharmacoepidemiology research in postmarketing surveillance and anesthesia practice critical care medicine
Despite tremendous efforts to ensure the safety and effectiveness of newly marketed medications, a number of these have had significant problems after introduction of the drug to the market.