Evolution of Circulating Tumor DNA Profile from First-line to Subsequent Therapy in Metastatic Renal Cell Carcinoma

Evolution of Circulating Tumor DNA Profile from First-line to Subsequent Therapy in Metastatic Renal Cell Carcinoma

Publication: Eur Urol

Background: Treatment of metastatic renal cell carcinoma (mRCC) typically entails mechanistically distinct agents across the first- and second-line setting.

Prediction of Losartan Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically-Based Pharmacokinetic Models.

Prediction of Losartan Active Carboxylic Acid Metabolite Exposure Following Losartan Administration Using Static and Physiologically-Based Pharmacokinetic Models.

Publication: J Pharm Sci
Software: GastroPlus®

The aim of this study was to evaluate a strategy based on static and dynamic physiologically based pharmacokinetic (PBPK) modeling for the prediction of metabolite and parent drug area under...

Development and qualification of physiologically based pharmacokinetic models for drugs with atypical distribution behavior: A desipramine case study.

Development and qualification of physiologically based pharmacokinetic models for drugs with atypical distribution behavior: A desipramine case study.

Publication: CPT Pharmacometrics Syst Pharmacol
Software: GastroPlus®
Division: PBPK

Desipramine is a secondary tricyclic amine, which is primarily metabolized by cytochrome 2D6. It shows a high volume of distribution (Vss) (10–50 L/kg) due to its high lipophilicity, unspecific phospholipid binding, and lysosomal trapping.

Food effect: The combined effect of media pH and viscosity on the gastrointestinal absorption of ciprofloxacin tablet

Food effect: The combined effect of media pH and viscosity on the gastrointestinal absorption of ciprofloxacin tablet

Publication: Eur J Pharm Sci
Software: GastroPlus®

The clinical implications of food-drug interactions may have to be taken seriously into account with oral drugs administration in order to minimize variations in drug bioavailability. 

Influence of different proton pump inhibitors on the pharmacokinetics of voriconazole

Influence of different proton pump inhibitors on the pharmacokinetics of voriconazole

Authors: Qi F, Zhu L, Li N, Ge T, Xu G, Liao S
Publication: Int J Antimicrob Agents
Software: GastroPlus®

This study aimed to determine the influence of proton pump inhibitors (PPIs) on the pharmacokinetics of voriconazole and to characterise potential drug-drug interactions (DDIs)...

In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation

In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation

Publication: J Control Release

Drug release from mesoporous silica systems has been widely investigated in vitro using USP Type II (paddle) dissolution apparatus.

Mechanistic prediction of food effects for Compound A tablet using PBPK model

Mechanistic prediction of food effects for Compound A tablet using PBPK model

Publication: Saudi J Biol Sci
Software: GastroPlus®
Division: PBPK

Physiologically based pharmacokinetic (PBPK) modeling has been extensively used to study the factors of effect drug absorption, distribution, metabolize and extraction progress in human.

In silico-in vitro-in vivo studies of experimentally designed carvedilol loaded silk fibroin-casein nanoparticles using physiological based pharmacokinetic model

In silico-in vitro-in vivo studies of experimentally designed carvedilol loaded silk fibroin-casein nanoparticles using physiological based pharmacokinetic model

Authors: Kumar S, Singh SK
Publication: Int J Biol Macromol
Software: GastroPlus®

The study aimed to design and develop carvedilol loaded silk fibroin-casein nanoparticles using 32 full factorial design.

Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose

Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose

Publication: Asian J Pharm Sci
Software: GastroPlus®

The purpose of this study was to develop an extended-release (ER) matrix tablet that shows robust dissolution properties able to account for the variability of pH and mechanical stress in the GI tract using...

Synthesis, spectral characterization, crystal structure, cytotoxicity and apoptosis—Inducing activity of two derivatives of 2-hydroxy-1,4-naphthaquinone

Synthesis, spectral characterization, crystal structure, cytotoxicity and apoptosis—Inducing activity of two derivatives of 2-hydroxy-1,4-naphthaquinone

Publication: Photodiagnosis Photodyn Ther

A phenaxazone compound [5H-Benzo[a]phenoxazin-5-one (BP)] along with an aminoquinone[2-[(o-hydroxyphenyl)amino]-1,4-naphthaquinone (HAN)] derivatives were synthesized from...

Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing

Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing

Publication: AAPS J
Software: GastroPlus®
Division: PBPK

The study aimed to characterise the mechanism of release and absorption of Basmisanil, a biopharmaceutics classification system (BCS) class 2 compound, from immediate-release formulations via mechanistic absorption modelling, dissolution testing, and Raman imaging.

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Intracellular drug bioavailability: a new predictor of system dependent drug disposition

Publication: Sci Rep
Software: ADMET Predictor®

Intracellular drug exposure is influenced by cell- and tissue-dependent expression of drug-transporting proteins and metabolizing enzymes.

Mechanistic understanding of the effect of renal impairment on metformin oral absorption using computer simulations

Mechanistic understanding of the effect of renal impairment on metformin oral absorption using computer simulations

Publication: J Pharm Invest

The physiological parameters that describe the reasons behind metformin accumulation in renal failure patients are not fully understood.

Vitamin K epoxide reductase regulation of androgen receptor activity

Vitamin K epoxide reductase regulation of androgen receptor activity

Publication: Oncotarget

Long-term use of warfarin has been shown to be associated with a reduced risk of prostate cancer. Warfarin belongs to the vitamin K antagonist class of anticoagulants, which...

Identification, characterization and in silico ADMET prediction of Roflumilast degradation products

Identification, characterization and in silico ADMET prediction of Roflumilast degradation products

Publication: J Pharm Biomed Anal
Software: ADMET Predictor®
Division: PBPK

The present study reports the degradation behavior of roflumilast (RFL), a new drug developed for the treatment of chronic obstructive pulmonary disease.