Drug design and development requires collaboration among scientists with diverse expertise.
Modeling of ayurveda ghee based solid lipid nano particles and their comprehensive pharmacokinetics study
Several experiments have been done with solid lipid nanoparticles (SLNPs) module to produce a potential oral drug delivery system.
Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool
The bioavailability of an orally administered small molecule is often dictated by drug-specific...
Holistic Prediction of the pKa in Diverse Solvents Based on a Machine‐Learning Approach
While many approaches to predict aqueous pKa values exist, the fast and accurate prediction of non‐aqueous pKa values is still challenging.
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability
The competence of hydrophilic interaction (HILIC) and reversed phase liquid chromatography (RPLC) modes, employing two new stationary phases...
Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system
The WHO Biopharmaceutical Classification System (BCS) is a practical tool to identify active pharmaceutical ingredients (APIs) that scientifically qualify for...
Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: Impact on safety assessments
A review of pharmacokinetic and metabolism studies show that triclopyr is well absorbed from the oral route in numerous species...
The art of atom descriptor design
This review provides an overview of descriptions of atoms applied to the understanding of phenomena like chemical reactivity and selectivity...
Estimation of Attainment of Steady‐State Conditions for Compounds With a Long Half‐Life
Half‐life is a standard result reported with analysis of pharmacokinetic data.
Phytocannabinoid drug-drug interactions and their clinical implications
Cannabis is a plant with a long history of human pharmacological use, both for recreational purposes and as a medicinal remedy.
Policy of Multisource Drug Products in Latin America: Opportunities and Challenges on the Application of Bioequivalence In Vitro Assays
Background: The replacement of traditional in vivo bioequivalence studies by in vitro dissolution assays, based on the biopharmaceutical classification system (BCS), has...
Biopharmaceutical characterization of rebamipide: The role of mucus binding in regional-dependent intestinal permeability
In this study, we aimed to elucidate biopharmaceutical characteristics of the anti-ulcer drug rebamipide, with special emphasis on the...
Computational Methods Used in Phytocompound-Based Drug Discovery
Phytocompounds are gaining popularity, due to lesser toxicity, greater bioavailability and high chemodiversity.
In silico models for genotoxicity and drug regulation
Whereas in the past, (Q)SAR methods have been largely used to support the design of new drugs, in the last few decades...
Application of synthetic membranes in establishing bio-predictive IVPT for testosterone transdermal gel
The current study investigated the use of synthetic membranes in developing a bio-predictive in vitro permeation testing (IVPT) method for 1.62% testosterone gel.
Evaluation of the effect of synthetic compounds derived from azidothymidine on MDA-MB-231 type breast cancer cells
The present study aimed to investigate the effect of AZT derivates containing tellurium (Te) on human breast cancer cell lines and the mechanisms...
Mechanistic Investigations Support Liver Safety of Ubrogepant
Small-molecule calcitonin gene–related peptide (CGRP) receptor antagonists have demonstrated therapeutic potential for the treatment of migraine.
In Vitro-In Silico Evaluation of Apremilast Solid Dispersions Prepared via Corotating Twin Screw Extruder
The purpose of this study was to employ the Hot melt extrusion technique (HME) to prepare amorphous solid dispersions (ASDs) of Apremilast, a BCS class IV drug.
Developing HME-Based Drug Products Using Emerging Science: a Fast-Track Roadmap from Concept to Clinical Batch
This paper presents a rational workflow for developing enabling formulations, such as amorphous solid dispersions, via hot-melt...
DILIsym: Quantitative systems toxicology impacting drug development
DILIsym®, a quantitative systems toxicology model developed over the last decade by the drug-induced liver injury (DILI)-sim Initiative, has provided novel...