The study aimed to investigate rifampicin (RIF) loaded cationic nanoemulsion (NE) for increased efficacy, facilitated intestinal...

GLORYx: Prediction of the Metabolites Resulting from Phase 1 and Phase 2 Biotransformations of Xenobiotics
Predicting the structures of metabolites formed in humans can provide advantageous insights for the development of drugs and other compounds.

In Silico studies of novel Sildenafil self-emulsifying drug delivery system absorption improvement for pulmonary arterial hypertension
Sildenafil is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for pulmonary...

Using a Physiologically Based Pharmacokinetic Absorption Model to Establish Dissolution Bioequivalence Safe Space for Oseltamivir in Adult and Pediatric Populations
Bioequivalence (BE) studies support the approval and clinical use of both new drug and generic drug products.

Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary
In vitro dissolution experiments are used to qualitatively assess the impact of formulation composition and process changes on the drug dosage form performance.

In silico Methods for Drug Design and Discovery
Computer-aided drug design (CADD) methodologies are playing an ever-increasing role in drug discovery that are critical in the cost-effective...

Identification and characterization of novel metabolites of nintedanib by ultra‐performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry with in silico toxicological assessment
Nintedanib, an oral, triple angiokinase inhibitor, is used alongside docetaxel in the management of locally recurrent non‐small‐cell lung cancer...

Forced degradation studies of medroxyprogesterone acetate injectable suspensions (150 mg/ml) with implementation of HPLC, mass spectrometry, and QSAR techniques
Medroxyprogesterone acetate (MPA) injectable products are a key commodity for reproductive health and are available in the global...

Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor
Chemicals have multiple effects in biological systems.

Chemical space and diversity of seaweed metabolite database (SWMD): A cheminformatics study
Seaweeds have attracted attention in the past decade as a biological source of highly diverse secondary metabolites with great potential in the...

Exploring QSAR models for assessment of acute fish toxicity of environmental transformation products of pesticides (ETPPs)
Environmental transformation products of pesticides (ETPPs) have a great deal of ecological impact owing to their ability to cause toxicity to the...

Fatty acid profile and in silico pharmacological study of diatom Amphora sp
Amphora sp. is a type of potential microalgae that has a considerably high content of lipid.

Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses
Exposure-response (E-R) models were developed to provide a description of the time-course of treatment effect for monthly and quarterly dosing regimens of...

Effect of the structural factors of organic compounds on the acute toxicity toward Daphnia magna
The acute toxicity of organic compounds towards Daphina magna was subjected to QSAR analysis.

Molecular engineering of safe and efficacious oral basal insulin
Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharmacological properties of these insulin analogues.

The good, the bad, and the ugly in chemical and biological data for machine learning
Machine learning and artificial intelligence (ML/AI) have become important research tools in molecular medicine and chemistry.

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Anti‐CD38 Cytolytic Antibody TAK‐079 in Healthy Subjects
This investigation characterised tolerability, pharmacokinetics and pharmacodynamics of the

Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D3 and Its Natural Derivatives
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements.

Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D 3 and Its Natural Derivatives
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements.
![Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging
[18F]FHBG has been used as a positron emission tomography (PET) imaging tracer for the monitoring of herpes simplex virus type 1 thymidine kinase...