Molecular modeling for potential cathepsin L inhibitor identification as new anti-photoaging agents from tropical medicinal plants

Molecular modeling for potential cathepsin L inhibitor identification as new anti-photoaging agents from tropical medicinal plants

Publication: J Bioenerg Biomemb
Software: ADMET Predictor®

Ultraviolet exposure can cause photoaging toward the human skin which is begun by the inflammation on the exposure area, also resulting in activation of a degradative enzyme cathepsin L.

Prediction of fraction unbound in plasma in children in data-limited scenarios for human health risk assessment

Prediction of fraction unbound in plasma in children in data-limited scenarios for human health risk assessment

Authors: Yun YE, Edginton AN
Publication: Computational Toxicology
Software: ADMET Predictor®

In human health risk assessment, pediatric physiologically-based pharmacokinetic modeling has been used to predict chemical-specific toxicokinetic adjustment factors.

Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin

Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin

Publication: AAPS PharmSciTech
Software: GastroPlus®

We focused to explore a suitable solvent for rifampicin (RIF) recommended for subcutaneous (sub-Q) delivery [ethylene glycol (EG), propylene glycol...

Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension

Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension

Publication: Int J Hypertension
Software: GastroPlus®
Division: PBPK

In case of absent liquid dosage form, crushing a tablet or dispersing a capsule would be the most convenient option for using these drugs in patients with dysphagia difficulties.

In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives

In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives

Authors: Huang Y, Yu Q, Chen Z, Wu W, Zhu Q, Lu Y
Publication: Acta Pharm Sin B
Software: GastroPlus®
Division: PBPK

Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs.

A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

Publication: Acta Pharm Sin B
Software: GastroPlus®
Division: PBPK

Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.

A Survey of the Regulatory Requirements for the Waiver of In Vivo Bioequivalence Studies of Generic Products in Certain Dosage Forms by Participating Regulators and Organisations of the International Pharmaceutical Regulators Programme

A Survey of the Regulatory Requirements for the Waiver of In Vivo Bioequivalence Studies of Generic Products in Certain Dosage Forms by Participating Regulators and Organisations of the International Pharmaceutical Regulators Programme

Publication: J Pharm Pharm Sci
Division: PBPK

The requirements to waive in vivo bioequivalence studies for immediate release solid oral dosage forms based on the Biopharmaceutics Classifications System (BCS) are well known, and biowaivers[1] for other types of oral dosage forms based on pre-defined criteria may also be acceptable.

Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Dogs

Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Dogs

Publication: Mol Pharm
Software: GastroPlus®
Division: PBPK

Colon absorption is a key determinant for the successful development of modified-release (MR) formulations, and the risk that colon absorption may limit the in vivo performance...

An IPRP survey of the regulatory requirements for the waiver of in vivo bioequivalence studies of generic medicinal products in certain dosage forms

An IPRP survey of the regulatory requirements for the waiver of in vivo bioequivalence studies of generic medicinal products in certain dosage forms

Publication: J Pharm Pharm Sci

The requirements to waive in vivo bioequivalence studies for immediate release solid oraldosage forms based on the Biopharmaceutics Classifications System (BCS) are well known, and biowaiversafor other types of oral dosage forms based on pre-defined criteria may also be acceptable.

Neutralization of European, South African, and United States SARS-CoV-2 mutants by a human antibody and antibody domains

Neutralization of European, South African, and United States SARS-CoV-2 mutants by a human antibody and antibody domains

Publication: bioRxiv

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) transmission with several emerging variants remain uncontrolled in many countries, indicating the pandemic remains severe.

Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Leveraging Oral Drug Development to a Next Level: Impact of the IMI-Funded OrBiTo Project on Patient Healthcare

Publication: Front Med (Lausanne)
Software: GastroPlus®
Division: PBPK

A thorough understanding of the behavior of drug formulations in the human gastrointestinal (GI) tract is essential when working in the field of oral drug development in a pharmaceutical company.

Prediction of Plasma Concentrations Using In Silico Modeling and Simulation Approach: Case of Acebutolol

Prediction of Plasma Concentrations Using In Silico Modeling and Simulation Approach: Case of Acebutolol

Authors: Bokri E, Felfel H, Bahri S
Publication: Ann Pharm Fr
Software: GastroPlus®
Division: PBPK

The aim of this study was to predict the plasma concentrations of acebutolol tablets with different dissolution profiles using computer modelling and evaluating whether they are bioequivalent using simulated population studies.