KAT6A and KAT6B genes are two closely related lysine acetyltransferases that transfer an acetyl group from acetyl coenzyme A (AcCoA) to lysine residues of target histone substrates, hence playing a key role in chromatin regulation.
PK/PD Modeling Made Simple
Modeling is increasingly important for the speed and success of our drug development programs, but the learning curve to be effective can be high.
Advancing Scientific Development with Collaborations
15+ FDA grants and $5M+ in funding & new feature developments since 2014
Transforming Clinical Trial Training for Enhanced Patient Trust
Patient trust is critical for ensuring adequate enrollment and retention of clinical trial participants.
Boosting Patient Safety with Risk-Free Adaptive Learning
Patient safety is paramount in any clinical trial.
GP AP Module Flyer
The ADMET Predictor Module uses enhanced pk models developed with greater accuracy. It uses the same QSPR models as our best-inclass ADMET Predictor standalone software.
GP DDI Module Flyer
The DDI Module in GastroPlus allows you to predict mechanistic and static drug-drug interactions (DDIs) among unlimited drugs and metabolites.
GP PKPlus™ Module Flyer
The fitted parameters include PK properties, first orderabsorption rate, bioavailability and absorption lag time.
Simulations Plus and the University of Southern California Secure NIH Grant to Develop New AI Drug Discovery Offerings
Partnership will advance the field of ligand-based virtual screening to improve drug design and optimization activities
The Case for PK Simulations in Early Drug Discovery
You’re the head of medicinal chemistry. Your focus is on developing molecules that balance (often conflicting) objectives to achieve the target compound profile, and it consumes every spare minute.
RENAsym Flyer
RENAsym Predict and Prevent Drug-Induced Kidney Injury
PBBM Considerations for Base Models, Model Validation, and Application Steps: Workshop Summary Report
The proceedings from the 30th August 2023 (Day 2) of the workshop “Physiologically Based Biopharmaceutics Models (PBBM) Best Practices for Drug Product Quality: Regulatory and Industry Perspectives” are provided herein.
Preparation and Evaluation of Nanolipid Carriers of Bedaquiline- In vitro Evaluation and in silico Prediction
Bedaquiline, a potent antitubercular drug used in the treatment of multidrug-resistant strains, suffers from low oral bioavailability, a slow onset of therapeutic action, and side effects.
Synthesis, Absolute Configuration, Biological Profile and Antiproliferative Activity of New 3,5-Disubstituted Hydantoins
Hydantoins, a class of five-membered heterocyclic compounds, exhibit diverse biological activities.
Leveraging PBPK/PBBM in Support of BCS Class 3 Biowaivers
It is critical to understand the perspectives and key criteria of global regulatory agencies in the consideration of biowaivers, but many companies have knowledge gaps that hinder their success.
Advancing the Harmonization of Biopredictive Methodologies through the Product Quality Research Institute (PQRI) Consortium: Biopredictive Dissolution of Dipyridamole Tablets
Biorelevant dissolution and its concept have been widely accepted and further developed to meaningfully predict the bioperformance of oral drug products.
Getting Started with GPX™: A Step-by-Step Guide
With a new interface, updated workflows, and advanced features, it may be challenging to know how to get started with GastroPlus(R) X.
Systematic Evaluation of Underlying Models That Improve Purely In-Silico High-Throughput Mechanistic Pbpk Predictions Across Species
The ability to quickly and accurately predict key PK properties based solely on chemical structure can aid in several tasks.
MonolixSuite™ v2024 Product Brochure
A fast easy-to-use and powerful suite of applications for pharmacometrics analysis, modeling and simulation.