Neil Miller, M.S
Vice President, PBPK Product Development
Physiologically Based Pharmacokinetics (PBPK) Solutions
About Neil
Neil Miller is the Vice President, PBPK Product Development at Simulations Plus, driving the development and application of physiologically based pharmacokinetic (PBPK) modeling software tools for the pharmaceutical, biotechnology, chemicals, and consumer goods industries. Previously he was at GlaxoSmithKline for over 20 years gaining experience of working in the pharmaceutical industry. His last position was as a Scientific Director within the Systems Modeling and Translational Biology group, leading a team of advanced PBPK specialists that provided end-to-end mechanistic modelling for drug discovery and development. Key activities included predicting efficacious human doses at Candidate Selection (CS) and supporting drug product development with physiologically based biopharmaceutics modeling (PBBM).
Neil’s early career was spent working in the drug metabolism and pharmacokinetic (DMPK) area. He progressed from a bioanalytical scientist working in the lab generating DMPK data to a discovery DMPK project coordinator identifying quality molecules for CS. He then discovered a passion for modeling and simulation, specializing in predicting human pharmacokinetics from preclinical data using both empirical and mechanistic based modeling approaches. Over the last decade he has focused on the application of PBPK modeling in drug discovery and development and led the vision to have PBPK models in place for all compounds prior to in vivo studies in a “model first experiment later” paradigm. He is the lead author of the impactful manuscript “Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies.”
Neil has an MSc in Medicinal Chemistry & Drug Metabolism from Loughborough University in the UK. Besides his professional work and family life, Neil is a keep-fit enthusiast.
