This is a beginner’s course for mechanistic modelers, pharmacologists, clinicians, pharmaceutical/biotechnology scientists, and engineers in the specific area of clinical and quantitative systems pharmacology (QSP) for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Prior experience with NAFLDsym is not required. The course will focus on NAFLDsym v2A, but many of the guiding principles will be taught in a software-independent manner. Class size is limited to encourage interaction with the course instructors and among attendees. Virtual networking among industry, government, and academic scientists is part of the experience!