Mechanistic Modeling of in vitro Assays to Improve in vitro/in vivo Extrapolation

Authors: Fraczkiewicz G, Lukacova V, Mullin JM
Conference: ISSX
Keywords: assay predicition, hepatocyte models, parameter sensitivity analysis, permeability, sandwich hepatocyte
Software: MembranePlus™
Division: PBPK

Overview

  • MembranePlus™ – a software platform for simulation of in vitro transport assays:

–Mechanisms

–Inputs

–Models

  • Case Studies

–In vitro model validation

–In vitro/in vivo extrapolation

22nd North American ISSX Meeting, July 15-19, 2018, Quebec Canada

Grace Fraczkiewicz, Viera Lukacova, Jim Mullin