Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic OATP1B1/1B3

Authors: Dong J, Olaleye OE, Jiang R, Li J, Lu C, Du F, Xu F, Yang J, Wang F, Jia W, Li C
Publication: Br J Pharmacol
Keywords: DDI predictions, hepatic uptake, liver, OATP, PBPK modeling, transporters
Software: GastroPlus®

Abstract

Intravenous glycyrrhizin, having anti‐inflammatory and hepatoprotective properties, is incorporated into the management of liver diseases in China. This investigation was designed to elucidate the molecular mechanism underlying hepatobiliary excretion of glycyrrhizin and to investigate its potential for drug‐drug interactions on organic anion‐transporting polypeptides (OATP)1B.