Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers

Authors: Hsieh DS, Luo L, Xu Y, Engstrom JD, Gao Q
Publication: Pharm Res
Keywords: alcoholysis degradation hydrolysis modeling PVPVA reaction kinetics, degradation, PBPK modeling, polymers, precipitation kinetics
Software: GastroPlus®

Purpose

To understand hydrolysis and alcoholysis of polyvinylpyrrolidone-co-vinylacetate (PVPVA) during formulation and storage, elucidate the reaction mechanism, establish an intrinsic kinetic model, and apply this model coupled with GastroPlus™ modeling to predict the amount of PVPVA degradation in vivo.