Pharmacokinetics/Pharmacodynamics in Otitis Media: Comparison of Time-Dependent Antibiotics in Middle Ear Fluid

Authors: Bhavnani SM, Ambrose PG, Rubino CM, Forrest A, Jones RN
Conference: IDSA
Keywords: Amoxicillin, anti-infectives, antibiotics, cefpodoxime, cefprozil, ceftibuten, ceftriaxone, cephalosporin, clarithromycin, dosing, infectious disease, MIC, minimum inhibitory concentration, Monte Carlo, Otolaryngology, pediatrics, PK/PD, pneumoniae, streptococcus, time-dependent
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Abstract

Background: An effective dosing regimen of b-lactam and macrolide antibiotics for otitis media involving S. pneumoniae (SP) requires that drug concentrations in middle ear fluid (MEF) remain above the MIC (T>MIC) of the isolate for at least 35-50% of the dosing interval. The purpose of these analyses was to determine the probability of obtaining 35-50% T>MIC in MEF using Monte Carlo simulation (MCS) for CDC-recommended (amoxicillin) or FDA-approved dosing regimens of AMX, cefaclor, cefprozil, cefixime, cefpodoxime, ceftibuten, ceftriaxone, and clarithromycin.

Infectious Diseases Society of America (IDSA), Chicago, Illinois, October 2002

By SM Bhavnani, PG Ambrose, CM Rubino, A Forrest, RN Jones