Introduction

Technical reports for pharmacometric modeling provide comprehensive documentation, typically including data assembly methods and disposition, modeling strategy, and analysis results. These reports, however, are costly and time consuming and do not necessarily serve the dynamic research and development lifecycle which requires an ongoing accretion of data from Phase 1, 2, and 3 trials. Cognigen implemented KIWI™ in 2011, a secure internet-based service providing high throughput NONMEM® processing. KIWI is the basis for a progressive reporting process that facilitates the capture of critical information during model development; enables team access to evolving, interim results; and facilitates rapid assembly of technical reports.

Twenty-Fourth Meeting of the Population Approach Group in Europe (PAGE): June 2-5, 2015, Crete, Greece

By Thaddeus H. Grasela, Sebastien Bihorel, Cynthia A. Walawander, Jill Fiedler-Kelly, David Fox, Andrew Rokitka