The representation of the innate immune response within the model scope includes macrophage (Kupffer) and liver sinusoidal endothelial cell (LSEC) populations. Macrophages and immunomodulatory molecules produced by macrophages have been shown to modify the hepatotoxicity in animal models and patients.
01. Discover
What is the Innate Immunity Submodel?
LSECs regulate immune cell recruitment to the liver and produce molecules that are involved in the regeneration phase in response to hepatocellular loss. Acetaminophen (APAP) serves as the primary exemplar compound as most of the available data characterizes the role of these cells and molecules in APAP hepatotoxicity. These include liposomal clodronate (for macrophage depletion), a HMGB1 antagonist, a TNF-α antagonist, and exogenous HGF.
02. Submodels
Learn more about other submodels within DILIsym®
DILIsym is Quantitative Systems Toxicology (QST) software designed to be used during drug development to provide an indication of the potential drug-induced liver injury (DILI) hazard posed by individual molecules and/or to provide deeper insight into the mechanisms responsible for observed DILI responses at various stages of the development process.
03. Resources
Peer-reviewed Publications
