Please join us at EUROTOX 2024 organized by The Danish Society of Toxicology and Pharmacology in Copenhagen, Denmark, September 8-11, 2024. Simulations Plus Senior Scientist, Physiologically Based Pharmacokinetics (PBPK) Solutions, Priyata Kalra will be presenting at the event.

The congress theme “Toxicology – A Quest for safe Chemicals and Medicines” reflects the congress program including a variety of topics dealing with safety of drugs and environmental chemicals, new and emerging technologies, personalized medicine, human health effects caused by exposure to chemicals as well as safety issues arising from climate changes.

Can’t Miss Presentations!

Predictive performance of physiologically based kinetic (PBK) models based on in-silico/in vitro- in vivo extrapolation (IS/IVIVE)
Session: In vitro to in vivo extrapolation (QIVIVE)
Presenter: Priyata Kalra, Senior Scientist
Date/Time: Monday, September 9th from 9:30-10:00 am
Location: Poster Viewing Area

Recent advancements in chemical risk assessment have emphasized the importance of new approach methodologies (NAMs), adhering to the 3R principles, increasingly utilizing in vitro assays for non-animal toxicity testing. These methods inform predictions of in vivo chemical levels in humans from in vitro data, supported by physiologically based kinetic (PBK) modeling, which integrates absorption, metabolism, and protein binding processes. The combination of non-testing (QSAR) and testing methods (in vitro assays) are pivotal in predicting in vivo exposure levels.

Framework for Classifying Chemicals for Repeat Dose Toxicity using NAMs
Session: Risk Prediction and Assessment /Risk assessment using New Approach Methodologies
Contributed to Publication: Priyata Kalra, Senior Scientist
Date/Time: Monday, September 9th from 3:30-4:00 pm
Location: Poster Viewing Area

EPAA’s ‘NAM Designathon 2023’ challenge for human toxicity sought to identify better classification systems capable of categorising chemicals for risk assessment based on their intrinsic toxicodynamic (TD) and toxicokinetic properties (TK) [1]. The aim of the challenge is to explore the use of non-animal methods (NAMs) to design a future classification system for systemic toxicity. The chemicals requiring assessment are identified by three levels of concern: low concern being those that could be used without restriction; medium concern requiring assessment in order to establish safe use levels; and high concern being candidates requiring risk management [2].

In this work, we propose a NAMs based classification system developed by ECETOC’s Staged Assessment Task Force integrating an evidence-based approach from three different workstreams:

• In silico predictions
• In vitro bioavailability (PBPK modelling and TK)
• In vitro bioactivity (TD)