Simulations Plus

A module that allows you to predict mechanistic and static DDIs among drugs and metabolites.

A module that allows for expanded simulation of distribution, elimination and concentrations of compounds throughout the body.

A module that enables you to obtain predictions from the structure of all physicochemical, pharmacokinetic and CYP metabolism kinetic parameters required for PBPK simulations.

A module that allows simulation of mechanistic absorption and disposition through dermal, intraoral, pulmonary, ocular, intramuscular and intraarticular routes.

A module that extends GastroPlus to include nonlinear pharmacokinetics into any compartment, along with metabolite tracking.

A module that simulates the systemic absorption and pharmacokinetics of biologics—for both monoclonal antibodies (mAb) and antibody-drug conjugates (ADCs).

A module that automatically fits key parameters to the data, optimizes study designs and doses, and “deconvolutes” in vivo release profiles to achieve target concentration v. time curves for parents and/or metabolites.

A module that allows you to fit standard pharmacodynamic (PD) models to observed data and to then use the fitted models to predict PD effect changes due to changes in dose, dosage form, and dosing regimens.

A module for rapidly estimating pharmacokinetic (PK) parameters for noncompartmental analysis (NCA), along with 1-, 2-, & 3-compartment PK models from pharmacokinetic studies (IV and/or oral) without the need to run full simulations.

A module that allows you to develop mechanistic and/or traditional correlations (IVIVC) between either in vitro release and in vivo release or in vitro release and absolute bioavailability, then use the correlation to predict plasma concentration-time profiles for formulations with different in vitro release rates or dose strengths.