Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid

Authors: Fagerberg JH, Karlsson E, Ulander J, Hanisch G, Bergstrom CAS
Publication: Pharm Res
Keywords: computer simulation, fasting, forecasting, humans, intestinal absorption, intestinal secretions, metabolism, pharmaceutical methods, solubility
Software: ADMET Predictor®

Purpose

To develop predictive models of apparent solubility (Sapp) of lipophilic drugs in fasted state simulated intestinal fluid (FaSSIF) and aspirated human intestinal fluid (HIF).