In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions

Authors: Karlgren M, Ahlin G, Bergstrom CAS, Svensson R, Palm J, Artursson P
Publication: Pharm Res
Keywords: drug-drug interactions (DDIs), in silico in vitro–in vivo extrapolation (IVIVE), inhibition, MRP2 OATP1B1
Software: ADMET Predictor®

Purpose

To establish in vitro and in silico models that predict clinical drug–drug interactions (DDIs) with the OATP1B1 (SLCO1B1) transporter.