Toxicological considerations of acetylcholinesterase reactivators

Authors: Voicu V, Radulescu FS, Medvedovici A
Publication: Expert Opin Drug Metab Toxicol
Keywords: AChE reactivators, acute toxicity, biodistribution, efficacy, OP intoxication, oximes, pharmacokinetics
Software: ADMET Predictor®

Introduction

The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles. Established structure–activity relationships are still unable to adequately predict their antidotal efficacy. However, the in vivo behavior of oximes is a direct consequence of their physico-chemical properties, considerably limiting the passive transport across the biological barriers.