Predicting Exposure After Oral Inhalation of the Selective Glucocorticoid Receptor Modulator, AZD5423, Based on Dose, Deposition Pattern, and Mechanistic Modeling of Pulmonary Disposition

Authors: Bäckman P, Tehler U, Olsson B
Publication: J Aerosol Med Pulm Drug Deliv
Keywords: anatomical mouth-throat model, AZD5423, deposition pattern, dissolution, inhalation, mechanistic modeling, pharmacokinetics, selective glucocorticoid receptor modulator, simulation

Background

Exposure following oral inhalation depends on the deposition pattern of the inhaled aerosol, the extent and rate of oral and pulmonary absorption, as well as systemic distribution and clearance. For lipophilic inhaled compounds with low water solubility and high permeability, the extent and rate of pulmonary absorption can be assumed dependent on deposition pattern as well as dissolution rate.