Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin

Authors: Parrott N, Hainzl D, Alberati D, Hofmann C, Robson R, Boutouyrie B, Martin-Facklam M
Publication: Clin Pharmacokinet
Keywords: biorelevant medium, electronic supplementary material, human pharmacokinetic, Physiologically based pharmacokinetic (PBPK) modeling, preclinical species
Software: GastroPlus®

Background

Bitopertin (RG1678) is a glycine reuptake inhibitor currently in phase 3 trials for treatment of schizophrenia. This paper describes the use of physiologically based pharmacokinetic (PBPK) modelling and preclinical data to gain insights into and predict bitopertin clinical pharmacokinetics.