Use of In Vitro-In Vivo Correlation to Predict the Pharmacokinetics of Several Products Containing a BCS Class 1 Drug in Extended Release Matrices

Authors: Mirza T, Bykadi SA, Ellison CD, Yang Y, Davit BM, Khan MA
Publication: Pharm Res
Keywords: area under curve, biological availability, biological models, computer simulation, cross-over studies, delayed-action preparations, humans, in vitro-in vivo correlation (IVIVC), oral administration, pharmaceutical preparations, pharmacokinetics, regression analysis, solubility
Software: GastroPlus®

Purpose

To determine if an IVIVC model can predict PK profiles of varying formulations of a BCS Class 1 drug that is a salt of a weak base.