Current status and gaps in mechanistic in-silico modeling for clinical translation and performance

Authors: Lukacova V
Conference: AAPS
Keywords: active pharmaceutical ingredient (API), clinical translation & performance, in silico, PBPK model
Software: GastroPlus®
Division: PBPK

Outline

  • PBPK model description
  • Exploring mechanisms affecting in vivo dissolution of low-solubility compound crystalline suspensions
    • Effect of inflammation
    • Example Paliperidone Palmitate
    • Effect of dissolution rate
    • Example Cabotegravir
  • Putting it all together

By Viera Lukacova

Presented at AAPS “Patient-Centric Design of Long-Acting Injectable Drug Products” Workshop Virtual Event March 9-10, 2022