3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

Authors: Jovanović M, Petrovic M, Cvijić S, Tomić N, Stojanović D, Ibric S, Uskoković P
Publication: Pharmaceutics
Keywords: formulation design, formulation design: gastroplus, gastroplus, intraoral, mechanistic absorption model, occat, oral cavity, pbbm, PBPK modeling, physiologically based biopharmaceutics
Software: GastroPlus®

Abstract

Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.

By Marija Jovanović, Miloš Petrović, Sandra Cvijić, Nataša Tomić, Dušica Stojanović, Svetlana Ibrić and Petar Uskoković