Concentration-QTc analysis of quizartinib in patients with relapsed/refractory acute myeloid leukemia

Authors: Huang H
Conference: SLP MIDD+
Keywords: acute myeloid leukemia, concentration-QTc modelling, Phase III, PopPK models, Quizartinib, SLP MIDD+ Virtual Conference, SLP2021MIDD
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Pharmacometrician, Hannah Huang, presents “Population Pharmacokinetic and Concentration-QTc Analysis of Quizartinib in Patients With FLT3-ITD–Positive Relapsed/Refractory ​Acute Myeloid Leukemia.”

Topics covered:

  • Development of PopPK models for quizartinib and its major metabolite (AC886) in a pooled analysis of 7 trials
  • Patient characteristics
  • C-QTc Analysis
  • and more!

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Presented at SLP MIDD+ Virtual Conference March 3-4, 2021